{"id":"0f7a46b1-bf8e-5a71-9b8b-35f76e752b44","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-renal-competition","predicate":"inhibits","statement":"Amino-acid loading experiments indicated inhibition of renal citrulline transport by arginine, lysine and ornithine.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"d10c9db9-5359-5111-a2a9-326b0eabd3bd","mechanism_event_label":"Related amino acids interacted at a kidney transport step.","subject":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"object":{"id":"7aab367e-bb55-5590-b7c6-ff8d442e8f6e","slug":"renal-citrulline-transport","display_name":"Renal citrulline transport in loading experiments","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d10c9db9-5359-5111-a2a9-326b0eabd3bd","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-renal-competition-event","event_type":"observed_relationship","label":"Related amino acids interacted at a kidney transport step.","description":"Amino-acid loading experiments indicated inhibition of renal citrulline transport by arginine, lysine and ornithine.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7aab367e-bb55-5590-b7c6-ff8d442e8f6e","slug":"renal-citrulline-transport","display_name":"Renal citrulline transport in loading experiments","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f53c7bfb-3b91-56fe-bebd-28623cfe13a0","slug":"citrulline","display_name":"L-Citrulline","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"c715e48e-42db-5fac-b4a4-c1285a68d085","slug":"ornithine","display_name":"L-Ornithine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Nine men in oral lysine tests; three men in intravenous amino-acid loading tests.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small historical experiment; no molecular transporter identified and no ordinary-meal effect size established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Arginine collection; tissue, species, dose and formulation distinctions retained.","comparator":null,"unit":null,"notes":"","entity":{"slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Related amino acids interacted at a kidney transport step.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"A new transport interaction of dibasic amino acids and citrulline in human kidney. · 1981 · https://pubmed.ncbi.nlm.nih.gov/6797099/ · DOI 10.1620/tjem.134.55","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"07171a56-1f8f-5c53-8fb2-03593fa570fe","evidence_kind":"source_excerpt","locator":"Lines 54-60","start_line":54,"end_line":60,"excerpt":"## arg-renal-competition\nRelated amino acids interacted at a kidney transport step.\nAmino-acid loading experiments indicated inhibition of renal citrulline transport by arginine, lysine and ornithine.\nModel: Nine men in oral lysine tests; three men in intravenous amino-acid loading tests.\nLimitations: Small historical experiment; no molecular transporter identified and no ordinary-meal effect size established.\nEvidence access: Primary abstract\nA new transport interaction of dibasic amino acids and citrulline in human kidney. · 1981 · https://pubmed.ncbi.nlm.nih.gov/6797099/ · DOI 10.1620/tjem.134.55","model_system":"Nine men in oral lysine tests; three men in intravenous amino-acid loading tests.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; primary evidence access stated per claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bb9a67ea-904f-5b8a-93a4-459081212bdd","stable_key":"import-fd37d270-3395-56d6-9f1c-ddda56e606f6","title":"L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"ec0e9a3fb72b7485534e4372a074ac7624a399ff962e55690eb462217b5149ec","revision_id":"af027270-5535-51ae-85ff-9c76c518c962","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}