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(2021). https://pubmed.ncbi.nlm.nih.gov/33200827/ DOI: 10.1113/jp280345","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestinal epithelium","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"caf5b696-3e8c-573e-80ee-90872397adc1","evidence_kind":"source_excerpt","locator":"Lines 697-711","start_line":697,"end_line":711,"excerpt":"### vdm-slc34a2-deletion-removes-calcitriol-phosphate-increment\nIntestine-specific Slc34a2 deletion eliminated the phosphate-transport increase induced by the tested calcitriol regimen.\nCondition category: machinery_impairment\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Without this intestinal transporter, active vitamin D failed to produce its usual phosphate-uptake increment.\norganism: Mus musculus\ntissue_or_cell_type: Intestinal epithelium\nexperimental_model: Wild-type and intestinal Slc34a2-deleted mice; active versus paracellular intestinal phosphate transport assays\nlimitations: Conditional transporter loss removes the measured hormonal increment; it does not prove that all baseline phosphate absorption is absent.\nexposure: Intraperitoneal calcitriol once daily for 2 days; dose not specified in the retrieved abstract.\ncross_nutrient: Vitamin D–calcium–phosphate regulation.\nevidence_locator: Abstract: reported experimental results\nnutrient: Vitamin D2 and D3\nevidence_scope: D3 active metabolite or VDR machinery experiment; not a direct D2-versus-D3 comparison.\n[vdm-hernando2021] 1,25(OH)2 vitamin D3 stimulates active phosphate transport but not paracellular phosphate absorption in mouse intestine. 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