{"id":"0f3949e7-d66e-562b-ad89-bc1adcc1b075","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-ffar2-agonist","predicate":"activates","statement":"Butyrate activated human GPR43/FFAR2 in the receptor-deorphanization assays.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3c0268f1-4128-5c66-bc47-cc4bbc503dcc","mechanism_event_label":"One cell-surface receptor detects short-chain fatty acids.","subject":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"object":{"id":"2339ae63-1f30-58c0-8b4f-1a46c8a87418","slug":"ffar2","display_name":"Human free fatty acid receptor 2 / FFAR2","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"3c0268f1-4128-5c66-bc47-cc4bbc503dcc","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-ffar2-agonist-event","event_type":"observed_relationship","label":"One cell-surface receptor detects short-chain fatty acids.","description":"Butyrate activated human GPR43/FFAR2 in the receptor-deorphanization assays.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2339ae63-1f30-58c0-8b4f-1a46c8a87418","slug":"ffar2","display_name":"Human free fatty acid receptor 2 / FFAR2","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human receptor expressed in yeast, mammalian cells and oocyte signaling systems.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Receptor activation alone does not establish a downstream clinical effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"One cell-surface receptor detects short-chain fatty acids.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12496283/ · DOI 10.1074/jbc.M211609200","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"512f9d6e-cd4a-5084-a123-1fad2e46fd51","evidence_kind":"source_excerpt","locator":"Lines 502-508","start_line":502,"end_line":508,"excerpt":"## butyrate-ffar2-agonist\nOne cell-surface receptor detects short-chain fatty acids.\nButyrate activated human GPR43/FFAR2 in the receptor-deorphanization assays.\nModel: Human receptor expressed in yeast, mammalian cells and oocyte signaling systems.\nLimitations: Receptor activation alone does not establish a downstream clinical effect.\nEvidence access: Primary abstract\nThe Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12496283/ · DOI 10.1074/jbc.M211609200","model_system":"Human receptor expressed in yeast, mammalian cells and oocyte signaling systems.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"33205bb8-dcbe-5d2c-afca-86075d7748d1","stable_key":"import-104835a3-b891-5dc4-a6bb-42ab7c6f96c4","title":"Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"a1253eb4426fc45d7b7c113028aa4ba2e9f89a9653272f3795437fc222bad558","revision_id":"c2320e65-a252-57a9-8838-7abf3d23400e","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}