{"id":"0f355300-3b30-5f69-a59e-4d1e1932296b","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-pth-response-depends-on-prior-status","predicate":"acutely-modulates","statement":"Mg administration promptly raised PTH in hypomagnesemic patients, whereas normal and hyperparathyroid comparison groups showed a decrease or little change.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8d67d7c9-b147-50ab-8b3d-a478dcee60d8","mechanism_event_label":"Restoring missing Mg can release a suppressed PTH response, while adding Mg in another starting state can inhibit it.","subject":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"object":{"id":"20086ed6-508d-540d-b23d-146f23a8990b","slug":"serum-pth-concentration","display_name":"Serum PTH concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8d67d7c9-b147-50ab-8b3d-a478dcee60d8","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-pth-response-depends-on-prior-status-event","event_type":"biochemical_relationship","label":"Restoring missing Mg can release a suppressed PTH response, while adding Mg in another starting state can inhibit it.","description":"Mg administration promptly raised PTH in hypomagnesemic patients, whereas normal and hyperparathyroid comparison groups showed a decrease or little change.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e162b0ab-1449-5471-b3c3-4638a0fa3a96","slug":"pth","display_name":"Parathyroid hormone / PTH","entity_type_key":"protein"},"role":"hormone endpoint","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"relevant concurrent mineral state","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"20086ed6-508d-540d-b23d-146f23a8990b","slug":"serum-pth-concentration","display_name":"Serum PTH concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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