{"id":"0ef6c72b-7c90-5c74-8d79-b63b1caec453","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-tpn-repletion","predicate":"improved","statement":"Ammonium molybdate improved the clinical condition, reversed the sulfur-handling defect and normalized urate production in the reported case.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"910e2523-1ccf-5588-bc6b-26faaa79bcd3","mechanism_event_label":"Replacement helped this documented acquired shortage.","subject":{"id":"5f4ae418-cc79-5335-83e9-aaa10b40723c","slug":"ammonium-molybdate","display_name":"Ammonium molybdate","entity_type_key":"small_molecule"},"object":{"id":"d7c8a43b-3ce2-59bb-8e28-14a5b29231a4","slug":"tpn-amino-acid-intolerance","display_name":"Amino-acid intolerance during parenteral nutrition","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"910e2523-1ccf-5588-bc6b-26faaa79bcd3","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-tpn-repletion-event","event_type":"observed_intervention","label":"Replacement helped this documented acquired shortage.","description":"Ammonium molybdate improved the clinical condition, reversed the sulfur-handling defect and normalized urate production in the reported case.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5f4ae418-cc79-5335-83e9-aaa10b40723c","slug":"ammonium-molybdate","display_name":"Ammonium molybdate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d7c8a43b-3ce2-59bb-8e28-14a5b29231a4","slug":"tpn-amino-acid-intolerance","display_name":"Amino-acid intolerance during parenteral nutrition","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/molybdenum-research/6795919.publisher-abstract.txt\", \"locator\": \"Exact primary publisher abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d2838a46a598539818059c1a1f8295e283334afced15326a6b5ba1a6104cbfd7\", \"start_char\": 0, \"end_char\": 1820, \"text_sha256\": \"d2838a46a598539818059c1a1f8295e283334afced15326a6b5ba1a6104cbfd7\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Single case during prolonged total parenteral nutrition","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Prolonged parenteral nutrition followed by ammonium molybdate","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Rare single case. 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