{"id":"0ef61d44-3163-501b-ab5d-05493dd81710","stable_key":"e37461ea-ea5d-5e2c-8091-138305f6dd70:l-aspartate-brown-ogc-lipids","predicate":"supports","statement":"Oxoglutarate-carrier silencing similarly increased small lipid droplets and impaired norepinephrine-induced lipolysis in mouse brown adipocytes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e8dc5680-18c6-50d4-b01a-63cafbaa80cb","mechanism_event_label":"A second carrier in the same shuttle also affected lipid mobilization.","subject":{"id":"f98eaea7-cc03-5666-8c20-b4f7f8df0d3a","slug":"mouse-slc25a11","display_name":"Mouse mitochondrial oxoglutarate carrier / Slc25a11","entity_type_key":"protein"},"object":{"id":"8b037979-0811-5d4f-b2b4-2bef292fc00a","slug":"mouse-brown-adipocyte-lipolysis","display_name":"Norepinephrine-stimulated lipolysis in mouse brown adipocytes","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e8dc5680-18c6-50d4-b01a-63cafbaa80cb","stable_key":"e37461ea-ea5d-5e2c-8091-138305f6dd70:l-aspartate-brown-ogc-lipids-event","event_type":"observed_relationship","label":"A second carrier in the same shuttle also affected lipid mobilization.","description":"Oxoglutarate-carrier silencing similarly increased small lipid droplets and impaired norepinephrine-induced lipolysis in mouse brown adipocytes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f98eaea7-cc03-5666-8c20-b4f7f8df0d3a","slug":"mouse-slc25a11","display_name":"Mouse mitochondrial oxoglutarate carrier / Slc25a11","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8b037979-0811-5d4f-b2b4-2bef292fc00a","slug":"mouse-brown-adipocyte-lipolysis","display_name":"Norepinephrine-stimulated lipolysis in mouse brown adipocytes","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0a0923d3-72b7-5d6a-bf3a-5a7a3071a09b","slug":"l-aspartate","display_name":"L-Aspartate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"628ddc2d-e4d9-59c7-ae76-0c0cab80a6b1","slug":"2-oxoglutarate","display_name":"2-Oxoglutarate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"a04ee5fe-ef31-5ee9-b4d1-8535bd5f9476","slug":"malate","display_name":"L-Malate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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