{"id":"0ef30d4a-4a6c-5e02-8aee-6c1d7e4b31c7","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-fgfr-activation","predicate":"promotes_activation_of","statement":"FGFR1 oxidation promoted receptor activation and downstream signaling in the phosphate-sensing tumor-model experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"73ad2821-cd1e-5784-b0a5-3cb04688011c","mechanism_event_label":"Phosphate triggered receptor signaling through an indirect chemical route.","subject":{"id":"2d65fff5-62ce-5e2d-8e3d-8df7336334f0","slug":"fgfr1-oxidation","display_name":"FGFR1 cysteine/methionine oxidation in the 2026 osteosarcoma study","entity_type_key":"cellular_process"},"object":{"id":"6aa2a908-0a89-5ac7-91ca-c3a41fc292e3","slug":"fgfr1","display_name":"Fibroblast growth factor receptor 1 / FGFR1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"73ad2821-cd1e-5784-b0a5-3cb04688011c","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-fgfr-activation-event","event_type":"biochemical_relationship","label":"Phosphate triggered receptor signaling through an indirect chemical route.","description":"FGFR1 oxidation promoted receptor activation and downstream signaling in the phosphate-sensing tumor-model experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2d65fff5-62ce-5e2d-8e3d-8df7336334f0","slug":"fgfr1-oxidation","display_name":"FGFR1 cysteine/methionine oxidation in the 2026 osteosarcoma study","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6aa2a908-0a89-5ac7-91ca-c3a41fc292e3","slug":"fgfr1","display_name":"Fibroblast growth factor receptor 1 / FGFR1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/phosphorus-research/42247296.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a8d4221d8a5c56a5937ab8262e3ece5ed87692cb876ddcc0a08e7f68b66a9b76\", \"start_char\": 0, \"end_char\": 1041, \"text_sha256\": \"a8d4221d8a5c56a5937ab8262e3ece5ed87692cb876ddcc0a08e7f68b66a9b76\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Osteosarcoma-cell signaling with in-vivo tumor experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Elevated phosphate challenges and receptor activation experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"New 2026 mechanism in tumor models; blood-Pi/tumor-growth association is not proof that dietary phosphorus causes human cancer. No specific transporter or oxidized residue number is invented from the abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Phosphorus research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Osteosarcoma cellular and animal systems; precise species not fully resolved from abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Phosphate triggered receptor signaling through an indirect chemical route.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[phosphorus-p42247296] Unconventional activation of the proto-oncogene FGFR1 by extracellular phosphate via H2O2-mediated kinase oxidation. 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No specific transporter or oxidized residue number is invented from the abstract.\nexposure: Elevated phosphate challenges and receptor activation experiments\nevidence_span: {\"source_cache\": \"artifacts/phosphorus-research/42247296.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a8d4221d8a5c56a5937ab8262e3ece5ed87692cb876ddcc0a08e7f68b66a9b76\", \"start_char\": 0, \"end_char\": 1041, \"text_sha256\": \"a8d4221d8a5c56a5937ab8262e3ece5ed87692cb876ddcc0a08e7f68b66a9b76\"}\n[phosphorus-p42247296] Unconventional activation of the proto-oncogene FGFR1 by extracellular phosphate via H2O2-mediated kinase oxidation. 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