{"id":"0ec7755e-dc42-5634-a34a-a96d2b0edc66","stable_key":"63ce713e-6aea-59f6-9896-ca30e010b2ce:l-tyrosine-cyb-bypass","predicate":"bypasses","statement":"The CYB561-deficient patients responded favorably to L-dihydroxyphenylserine, a precursor that can be converted directly to norepinephrine.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3b803f9e-5e09-546c-be0d-87a773f4a47a","mechanism_event_label":"A downstream precursor can bypass a particular broken step.","subject":{"id":"934e1fc8-348f-5945-a9cd-b4d06da461db","slug":"l-dihydroxyphenylserine","display_name":"L-Dihydroxyphenylserine / droxidopa","entity_type_key":"small_molecule"},"object":{"id":"48ab25cc-499f-5a96-9532-fd140fe1e275","slug":"human-cyb561-vesicular-catecholamine-synthesis","display_name":"Human CYB561-dependent vesicular catecholamine synthesis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3b803f9e-5e09-546c-be0d-87a773f4a47a","stable_key":"63ce713e-6aea-59f6-9896-ca30e010b2ce:l-tyrosine-cyb-bypass-event","event_type":"observed_relationship","label":"A downstream precursor can bypass a particular broken step.","description":"The CYB561-deficient patients responded favorably to L-dihydroxyphenylserine, a precursor that can be converted directly to norepinephrine.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"934e1fc8-348f-5945-a9cd-b4d06da461db","slug":"l-dihydroxyphenylserine","display_name":"L-Dihydroxyphenylserine / droxidopa","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"48ab25cc-499f-5a96-9532-fd140fe1e275","slug":"human-cyb561-vesicular-catecholamine-synthesis","display_name":"Human CYB561-dependent vesicular catecholamine synthesis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bcfef85f-831d-5439-ba51-1aef4b090441","slug":"l-tyrosine","display_name":"L-Tyrosine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"34ab29ee-eb2b-5e51-9d25-0c1f8d5b97d9","slug":"norepinephrine","display_name":"Norepinephrine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"cdc3fa8b-c680-5b62-bac0-f4d9b3baed95","slug":"ddc","display_name":"Human aromatic L-amino acid decarboxylase / DDC","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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