{"id":"0e5afbc3-2778-58d0-b4b7-081a852485d8","stable_key":"c94a9824-35fb-523c-b421-dc7341218dcb:indicaxanthin-perferryl-hb","predicate":"reduces_redox_state","statement":"Indicaxanthin reduced the perferryl-haemoglobin intermediate in the spectrophotometric reaction system.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"9ae64689-9385-50f5-83b3-2c67e41f29b3","mechanism_event_label":"Indicaxanthin reduced the perferryl-haemoglobin intermediate in the spectrophotometric reaction system.","subject":{"id":"f2a6e469-05f0-5596-9054-da926389f584","slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"},"object":{"id":"f090461c-617a-5ede-8385-f0b3da773af0","slug":"perferryl-hemoglobin-assay-state","display_name":"Perferryl haemoglobin in the indicaxanthin redox assay","entity_type_key":"protein_state"},"evidence_count":1,"mechanism_event":{"id":"9ae64689-9385-50f5-83b3-2c67e41f29b3","stable_key":"c94a9824-35fb-523c-b421-dc7341218dcb:indicaxanthin-perferryl-hb-event","event_type":"observed_relationship","label":"Indicaxanthin reduced the perferryl-haemoglobin intermediate in the spectrophotometric reaction system.","description":"Indicaxanthin reduced the perferryl-haemoglobin intermediate in the spectrophotometric reaction system.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f2a6e469-05f0-5596-9054-da926389f584","slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f090461c-617a-5ede-8385-f0b3da773af0","slug":"perferryl-hemoglobin-assay-state","display_name":"Perferryl haemoglobin in the indicaxanthin redox assay","entity_type_key":"protein_state"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"da9d64bc-69d4-5d97-90a4-8f0ed03e0ac8","slug":"hydrogen-peroxide","display_name":"Hydrogen peroxide","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Indicaxanthin compared with Trolox and vitamin C; exact concentrations not in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Spectrophotometric kinetic assay","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cell-free haemoglobin redox preparation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A haemoglobin intermediate was reduced; dietary iron chelation and human treatment efficacy were not established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Dedicated indicaxanthin chapter; original betalain family identity and shared claims preserved.","comparator":null,"unit":null,"notes":"","entity":{"slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Cell-free haemoglobin redox preparation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Indicaxanthin reduced the perferryl-haemoglobin intermediate in the spectrophotometric reaction system.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Cytoprotective effects of the antioxidant phytochemical indicaxanthin in beta-thalassemia red blood cells. (2006). https://pubmed.ncbi.nlm.nih.gov/16984002/ DOI: 10.1080/10715760600554228","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro addition","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Met-Hb/peroxide reaction mixture","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"243b622e-db9d-584a-834d-04a6d55b3dca","evidence_kind":"source_excerpt","locator":"Lines 52-61","start_line":52,"end_line":61,"excerpt":"## indicaxanthin-perferryl-hb\nIndicaxanthin reduced the perferryl-haemoglobin intermediate in the spectrophotometric reaction system.\nModel/species: Cell-free haemoglobin redox preparation\nTissue: Met-Hb/peroxide reaction mixture\nExposure: Indicaxanthin compared with Trolox and vitamin C; exact concentrations not in accessed abstract\nRoute: In vitro addition\nDuration: Spectrophotometric kinetic assay\nLimits: A haemoglobin intermediate was reduced; dietary iron chelation and human treatment efficacy were not established.\nPrimary reference: Cytoprotective effects of the antioxidant phytochemical indicaxanthin in beta-thalassemia red blood cells. (2006). https://pubmed.ncbi.nlm.nih.gov/16984002/ DOI: 10.1080/10715760600554228\nAccess: Primary PubMed abstract.","model_system":"Cell-free haemoglobin redox preparation","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived curation span; original paraphrase with primary citation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"18b7303c-98b7-54cb-ae8e-a8c6257657b1","stable_key":"import-c94a9824-35fb-523c-b421-dc7341218dcb","title":"Indicaxanthin: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen additional primary studies, with twenty-six existing claims from eight studies linked unchanged. Study-specific citations and limitations retained. 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