{"id":"0e47973c-f3ef-57e0-b8a3-073ac2059efc","stable_key":"d2e91bc7-8177-5ad3-ad9b-5d65813ce082:naringenin-oatp-inhibition","predicate":"inhibits","statement":"Selected naringenin sulfate or glucuronide conjugates potently inhibited OATP1B1 and/or OATP2B1 in vitro.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"62737a7f-e8a2-5c9a-bfda-b3244c3f081c","mechanism_event_label":"Selected naringenin sulfate or glucuronide conjugates potently inhibited OATP1B1 and/or OATP2B1 in vitro.","subject":{"id":"8d3fb1b0-bcda-52f6-9999-0259e2e56630","slug":"naringenin-sulfate-pool","display_name":"Naringenin sulfate conjugates","entity_type_key":"small_molecule"},"object":{"id":"d2900dd8-0902-5c08-9855-79debdad9462","slug":"human-oatp1b1-oatp2b1-transport","display_name":"Human OATP1B1/OATP2B1 transport activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"62737a7f-e8a2-5c9a-bfda-b3244c3f081c","stable_key":"d2e91bc7-8177-5ad3-ad9b-5d65813ce082:naringenin-oatp-inhibition-event","event_type":"observed_relationship","label":"Selected naringenin sulfate or glucuronide conjugates potently inhibited OATP1B1 and/or OATP2B1 in vitro.","description":"Selected naringenin sulfate or glucuronide conjugates potently inhibited OATP1B1 and/or OATP2B1 in vitro.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8d3fb1b0-bcda-52f6-9999-0259e2e56630","slug":"naringenin-sulfate-pool","display_name":"Naringenin sulfate conjugates","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d2900dd8-0902-5c08-9855-79debdad9462","slug":"human-oatp1b1-oatp2b1-transport","display_name":"Human OATP1B1/OATP2B1 transport activity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"38b2f200-15ca-5db6-8d7e-2b78ee490eda","slug":"slco1b1","display_name":"Human OATP1B1 / SLCO1B1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"4f63ef8a-7938-5fb2-bc0f-cca962df8510","slug":"slco2b1","display_name":"Human organic anion transporting polypeptide 2B1 / SLCO2B1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"d7acec3a-1dbb-5111-8767-2cd739c8939e","slug":"naringenin-glucuronide-pool","display_name":"Naringenin glucuronide conjugates","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Naringenin metabolite concentration-response","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Acute","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Transporter expression assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The abstract does not assign every conjugate to each transporter or establish interaction at human free concentrations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Naringenin chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"naringenin","display_name":"Naringenin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Transporter expression assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Selected naringenin sulfate or glucuronide conjugates potently inhibited OATP1B1 and/or OATP2B1 in vitro.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Interaction of luteolin, naringenin, and their sulfate and glucuronide conjugates with human serum albumin, cytochrome P450 (CYP2C9, CYP2C19, and CYP3A4) enzymes and organic anion transporting polypeptide (OATP1B1 and OATP2B1) transporters. 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(2023). https://pubmed.ncbi.nlm.nih.gov/36481402/ DOI: 10.1016/j.biopha.2022.114078\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Transporter expression assays","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2804932d-46eb-5c43-8a45-0505e6b1ee05","stable_key":"import-d2e91bc7-8177-5ad3-ad9b-5d65813ce082","title":"Naringenin: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. 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