{"id":"0e43a7c0-6940-566f-b4a6-b253cd41c2ad","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-deficiency-epo-transcript","predicate":"deficiency_reduces","statement":"Vitamin A deficiency reduced renal Epo mRNA in the rat experiment.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"79b5be40-0a3a-5229-8327-226cb16defb4","mechanism_event_label":"A shortage affected expression of an erythropoietic signal.","subject":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"object":{"id":"4f99fd38-8892-5993-a095-0c6bb1bb21a4","slug":"epo-mrna","display_name":"EPO mRNA","entity_type_key":"rna"},"evidence_count":1,"mechanism_event":{"id":"79b5be40-0a3a-5229-8327-226cb16defb4","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-deficiency-epo-transcript-event","event_type":"biochemical_relationship","label":"A shortage affected expression of an erythropoietic signal.","description":"Vitamin A deficiency reduced renal Epo mRNA in the rat experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"47ad89a2-2a43-51b7-8af4-f415f606b5b6","slug":"epo","display_name":"Erythropoietin","entity_type_key":"protein"},"role":"protein_identity","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"erythropoiesis_context","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"4f99fd38-8892-5993-a095-0c6bb1bb21a4","slug":"epo-mrna","display_name":"EPO mRNA","entity_type_key":"rna"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Renal gene-expression assay.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not by itself measure circulating EPO or prove ineffective erythropoiesis mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A shortage affected expression of an erythropoietic signal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[va-cunha2014] Vitamin A deficiency modulates iron metabolism via ineffective erythropoiesis (2014). https://pubmed.ncbi.nlm.nih.gov/24998947/ DOI: 10.1016/j.jnutbio.2014.05.005","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Kidney","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"03fb5eac-1578-58ff-8251-9ab18364065a","evidence_kind":"source_excerpt","locator":"Lines 1755-1764","start_line":1755,"end_line":1764,"excerpt":"### va-deficiency-epo-transcript\nVitamin A deficiency reduced renal Epo mRNA in the rat experiment.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A shortage affected expression of an erythropoietic signal.\norganism: Rattus norvegicus\ntissue_or_cell_type: Kidney\nexperimental_model: Renal gene-expression assay.\nlimitations: Does not by itself measure circulating EPO or prove ineffective erythropoiesis mediation.\n[va-cunha2014] Vitamin A deficiency modulates iron metabolism via ineffective erythropoiesis (2014). https://pubmed.ncbi.nlm.nih.gov/24998947/ DOI: 10.1016/j.jnutbio.2014.05.005","model_system":"Renal gene-expression assay.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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