{"id":"0e21f465-c525-5984-8267-24bfc977b2be","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-imp-human-association","predicate":"associates_with","statement":"Circulating imidazole propionate was higher in the studied people with type 2 diabetes than comparison participants.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d5dc05a1-fa14-5565-83f0-0cdc9668459d","mechanism_event_label":"A histidine-derived microbial metabolite tracked a metabolic phenotype.","subject":{"id":"06c093ed-025c-54bc-8016-6a3da64ffbf9","slug":"imidazole-propionate","display_name":"Imidazole propionate","entity_type_key":"small_molecule"},"object":{"id":"08777aaf-9ce5-5aa6-8d93-487b608f27da","slug":"human-type2-diabetes-imp","display_name":"Circulating imidazole propionate in type 2 diabetes","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d5dc05a1-fa14-5565-83f0-0cdc9668459d","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-imp-human-association-event","event_type":"observed_relationship","label":"A histidine-derived microbial metabolite tracked a metabolic phenotype.","description":"Circulating imidazole propionate was higher in the studied people with type 2 diabetes than comparison participants.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"06c093ed-025c-54bc-8016-6a3da64ffbf9","slug":"imidazole-propionate","display_name":"Imidazole propionate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"08777aaf-9ce5-5aa6-8d93-487b608f27da","slug":"human-type2-diabetes-imp","display_name":"Circulating imidazole propionate in type 2 diabetes","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"44374451-3436-5136-a8ae-5dcc6d8c353b","slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human observational metabolomics.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Association alone does not establish direction, causality or an individual diagnostic threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Histidine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A histidine-derived microbial metabolite tracked a metabolic phenotype.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30401435/ · DOI 10.1016/j.cell.2018.09.055","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8483b0d5-a9a1-5004-848b-0aa401eebca4","evidence_kind":"source_excerpt","locator":"Lines 290-296","start_line":290,"end_line":296,"excerpt":"## histidine-imp-human-association\nA histidine-derived microbial metabolite tracked a metabolic phenotype.\nCirculating imidazole propionate was higher in the studied people with type 2 diabetes than comparison participants.\nModel: Human observational metabolomics.\nLimitations: Association alone does not establish direction, causality or an individual diagnostic threshold.\nEvidence access: Primary abstract\nMicrobially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30401435/ · DOI 10.1016/j.cell.2018.09.055","model_system":"Human observational metabolomics.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"ce59e6c9-1213-523b-9d0b-400b7a81cd1c","stable_key":"import-911fb3c7-8cc3-5667-b677-5682fab67648","title":"L-Histidine: supply, catabolism, histamine, receptors and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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