{"id":"0e183e45-fcdf-529f-a98b-08e47993defb","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-sport-null","predicate":"does_not_significantly_reduce_tested","statement":"The red yeast rice arm of SPORT did not significantly lower LDL versus placebo after 28 days; rosuvastatin 5 mg did.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"0776b369-c431-563e-9a53-1dd5cb7d9da7","mechanism_event_label":"Another preparation and protocol did not demonstrate the same lipid result.","subject":{"id":"d889deda-a495-5c69-be5c-5501c6cd76d4","slug":"ryr-sport-2022-preparation","display_name":"Red yeast rice preparation in the SPORT trial","entity_type_key":"chemical_species"},"object":{"id":"ac5f5914-4824-5f9b-93c7-a6b5a52b53af","slug":"ldl-cholesterol-concentration","display_name":"LDL cholesterol concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0776b369-c431-563e-9a53-1dd5cb7d9da7","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-sport-null-event","event_type":"observed_relationship","label":"Another preparation and protocol did not demonstrate the same lipid result.","description":"The red yeast rice arm of SPORT did not significantly lower LDL versus placebo after 28 days; rosuvastatin 5 mg did.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d889deda-a495-5c69-be5c-5501c6cd76d4","slug":"ryr-sport-2022-preparation","display_name":"Red yeast rice preparation in the SPORT trial","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ac5f5914-4824-5f9b-93c7-a6b5a52b53af","slug":"ldl-cholesterol-concentration","display_name":"LDL cholesterol concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Single-center randomized trial; 190 participants completed all study arms combined.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Do not treat 190 as the red yeast rice sample size. Different product, duration and population from the Becker or Xuezhikang trials.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Another preparation and protocol did not demonstrate the same lipid result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[36351465] Comparative Effects of Low-Dose Rosuvastatin, Placebo, and Dietary Supplements on Lipids and Inflammatory Biomarkers. · 2023 · https://pubmed.ncbi.nlm.nih.gov/36351465/ · DOI 10.1016/j.jacc.2022.10.013","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3cf70595-183a-5199-8e33-462bb039403c","evidence_kind":"source_excerpt","locator":"Lines 356-362","start_line":356,"end_line":362,"excerpt":"## red-yeast-rice-sport-null\nAnother preparation and protocol did not demonstrate the same lipid result.\nThe red yeast rice arm of SPORT did not significantly lower LDL versus placebo after 28 days; rosuvastatin 5 mg did.\nModel: Single-center randomized trial; 190 participants completed all study arms combined.\nLimitations: Do not treat 190 as the red yeast rice sample size. Different product, duration and population from the Becker or Xuezhikang trials.\nEvidence access: Primary abstract\n[36351465] Comparative Effects of Low-Dose Rosuvastatin, Placebo, and Dietary Supplements on Lipids and Inflammatory Biomarkers. · 2023 · https://pubmed.ncbi.nlm.nih.gov/36351465/ · DOI 10.1016/j.jacc.2022.10.013","model_system":"Single-center randomized trial; 190 participants completed all study arms combined.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"261a12bc-3d00-52a4-a5ec-70e174390596","stable_key":"import-4910e17b-aaec-52cd-b9e5-caca85d817ee","title":"Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"271bbcecaaacc76ad4d06718ae592dc6a1b33e3e459adfdd36cbd0ac5f09c0f6","revision_id":"9c30956c-206c-5c49-ae42-81b070088e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}