{"id":"0e11778a-cdea-5272-bffc-ff04c7de3ae0","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-microbiome","predicate":"alters","statement":"EGCG-exposed fermentations showed increases in Bacteroides, Christensenellaceae and Bifidobacterium and decreases in selected other taxa.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"09d44c9b-6f9c-5f44-b0dd-4cbcadf0bb09","mechanism_event_label":"EGCG also changed the experimental microbial community.","subject":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"object":{"id":"85103e62-6f56-55c5-bd5a-d9db0eefe88c","slug":"gut-community-composition","display_name":"Gut microbial community composition in fermentation assays","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"09d44c9b-6f9c-5f44-b0dd-4cbcadf0bb09","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-microbiome-event","event_type":"observed_relationship","label":"EGCG also changed the experimental microbial community.","description":"EGCG-exposed fermentations showed increases in Bacteroides, Christensenellaceae and Bifidobacterium and decreases in selected other taxa.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"85103e62-6f56-55c5-bd5a-d9db0eefe88c","slug":"gut-community-composition","display_name":"Gut microbial community composition in fermentation assays","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"In-vitro fermentation with microbiome profiling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Taxon shifts and metabolite correlations do not establish a universally beneficial microbiome in humans.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"EGCG also changed the experimental microbial community.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Reciprocal Interactions between Epigallocatechin-3-gallate (EGCG) and Human Gut Microbiota In Vitro. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32808768/ · DOI 10.1021/acs.jafc.0c03587","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6ee4f4d7-92c4-55e0-b0d5-304bb37ab29a","evidence_kind":"source_excerpt","locator":"Lines 324-330","start_line":324,"end_line":330,"excerpt":"## egcg-microbiome\nEGCG also changed the experimental microbial community.\nEGCG-exposed fermentations showed increases in Bacteroides, Christensenellaceae and Bifidobacterium and decreases in selected other taxa.\nModel: In-vitro fermentation with microbiome profiling.\nLimitations: Taxon shifts and metabolite correlations do not establish a universally beneficial microbiome in humans.\nEvidence access: primary abstract.\nReciprocal Interactions between Epigallocatechin-3-gallate (EGCG) and Human Gut Microbiota In Vitro. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32808768/ · DOI 10.1021/acs.jafc.0c03587","model_system":"In-vitro fermentation with microbiome profiling.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}