{"id":"0e0288f3-891f-5038-8763-4e35fc778488","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-plasma-apo-detection","predicate":"associated_with_detected","statement":"Apo-6-, 8-, 10-, 12- and 14-prime lycopenals were detected in foods and human plasma; the plasma sum was 1.9 nmol/L.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9b9323dd-4244-5d18-8dbc-5d6e2ecab526","mechanism_event_label":"Finding a breakdown product in blood does not tell us where it was made.","subject":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"object":{"id":"8ab46ba7-0a7c-55c1-b03d-97ab546db32d","slug":"plasma-apo-lycopenals","display_name":"Circulating apo-lycopenals, individual species specified in study","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9b9323dd-4244-5d18-8dbc-5d6e2ecab526","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-plasma-apo-detection-event","event_type":"observed_intervention","label":"Finding a breakdown product in blood does not tell us where it was made.","description":"Apo-6-, 8-, 10-, 12- and 14-prime lycopenals were detected in foods and human plasma; the plasma sum was 1.9 nmol/L.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"00f65e41-237c-5844-bafe-0daf6ee73207","slug":"apo-10-lycopenal","display_name":"Apo-10-prime-lycopenal","entity_type_key":"small_molecule"},"role":"identified_product","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8ab46ba7-0a7c-55c1-b03d-97ab546db32d","slug":"plasma-apo-lycopenals","display_name":"Circulating apo-lycopenals, individual species specified in study","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lycopene-research/20178389.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"eddfd89ee638c7e574f322fcba2dd9b82b006f235f98a845962fe12b47d0987d\", \"start_char\": 0, \"end_char\": 1451, \"text_sha256\": \"eddfd89ee638c7e574f322fcba2dd9b82b006f235f98a845962fe12b47d0987d\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"HPLC-MS/MS measurement of food and human plasma metabolites","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Tomato juice for eight weeks; chemically prepared analytical standards","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Detection cannot separate absorbed food metabolites from enzymatic or nonenzymatic formation in the body.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lycopene research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human plasma and foods","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Finding a breakdown product in blood does not tell us where it was made.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lycopene-p20178389] Identification and quantification of apo-lycopenals in fruits, vegetables, and human plasma. (2010). https://pubmed.ncbi.nlm.nih.gov/20178389/ DOI: 10.1021/jf100415z","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma after tomato juice consumption; food extracts","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"adb7c00a-0faa-54b3-b29b-fc3f15707e51","evidence_kind":"source_excerpt","locator":"Lines 403-414","start_line":403,"end_line":414,"excerpt":"### lycopene-plasma-apo-detection\nApo-6-, 8-, 10-, 12- and 14-prime lycopenals were detected in foods and human plasma; the plasma sum was 1.9 nmol/L.\nCondition category: normal\nnutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Finding a breakdown product in blood does not tell us where it was made.\norganism: Human plasma and foods\ntissue_or_cell_type: Plasma after tomato juice consumption; food extracts\nexperimental_model: HPLC-MS/MS measurement of food and human plasma metabolites\nlimitations: Detection cannot separate absorbed food metabolites from enzymatic or nonenzymatic formation in the body.\nexposure: Tomato juice for eight weeks; chemically prepared analytical standards\nevidence_span: {\"source_cache\": \"artifacts/lycopene-research/20178389.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"eddfd89ee638c7e574f322fcba2dd9b82b006f235f98a845962fe12b47d0987d\", \"start_char\": 0, \"end_char\": 1451, \"text_sha256\": \"eddfd89ee638c7e574f322fcba2dd9b82b006f235f98a845962fe12b47d0987d\"}\n[lycopene-p20178389] Identification and quantification of apo-lycopenals in fruits, vegetables, and human plasma. 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