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molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Strontium can engage a receptor normally used to sense extracellular calcium.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The Calcium-sensing Receptor (CaR) is involved in strontium ranelate-induced osteoblast differentiation and mineralization. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20560105/ · DOI 10.1055/s-0030-1255091","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cd434eed-72cc-544e-a2e1-caab5a72abe3","evidence_kind":"source_excerpt","locator":"Lines 70-76","start_line":70,"end_line":76,"excerpt":"## strontium-human-casr\nStrontium can engage a receptor normally used to sense extracellular calcium.\nStrontium chloride and the ranelate preparation stimulated ERK phosphorylation in HEK293 cells transfected with human CaSR.\nModel: Human receptor transfection and dose-response signaling assays.\nLimitations: Receptor signaling is not itself proof of stronger bone or a nutritional requirement.\nEvidence access: Primary abstract\nThe Calcium-sensing Receptor (CaR) is involved in strontium ranelate-induced osteoblast differentiation and mineralization. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20560105/ · DOI 10.1055/s-0030-1255091","model_system":"Human receptor transfection and dose-response signaling assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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