{"id":"0d9d4366-a9ce-5e17-9e72-355a359356d0","stable_key":"10aa417f-4b03-599f-a453-4aa09edeb27c:alanine-fasting-flux-limit","predicate":"reduces","statement":"Total forearm amino acid release decreased during prolonged fasting even though alanine retained a prominent interorgan role.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"d0341592-02cd-5fb5-91d3-b47c1b61ec2d","mechanism_event_label":"The same pathway can remain important while its overall flow declines.","subject":{"id":"999efb84-817a-5ed2-a9a6-f8a0c692b706","slug":"human-prolonged-fasting","display_name":"Prolonged fasting in humans","entity_type_key":"cellular_process"},"object":{"id":"e035b551-0d5f-54e7-9190-2dd246148832","slug":"human-forearm-total-amino-acid-release","display_name":"Total forearm amino acid release","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d0341592-02cd-5fb5-91d3-b47c1b61ec2d","stable_key":"10aa417f-4b03-599f-a453-4aa09edeb27c:alanine-fasting-flux-limit-event","event_type":"observed_relationship","label":"The same pathway can remain important while its overall flow declines.","description":"Total forearm amino acid release decreased during prolonged fasting even though alanine retained a prominent interorgan role.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"999efb84-817a-5ed2-a9a6-f8a0c692b706","slug":"human-prolonged-fasting","display_name":"Prolonged fasting in humans","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e035b551-0d5f-54e7-9190-2dd246148832","slug":"human-forearm-total-amino-acid-release","display_name":"Total forearm amino acid release","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ebdc4461-c059-563e-88b0-422c21fdaa25","slug":"alanine","display_name":"L-Alanine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human balance measurements during prolonged fasting.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a recommendation for prolonged fasting, nor evidence for a fixed whole-body alanine flux.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Alanine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"alanine","display_name":"L-Alanine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The same pathway can remain important while its overall flow declines.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Alanine: key role in gluconeogenesis. · 1970 · https://pubmed.ncbi.nlm.nih.gov/5411169/ · DOI 10.1126/science.167.3920.1003","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"94a30ab4-4acc-5a83-8efa-3e0a23563142","evidence_kind":"source_excerpt","locator":"Lines 24-30","start_line":24,"end_line":30,"excerpt":"## alanine-fasting-flux-limit\nThe same pathway can remain important while its overall flow declines.\nTotal forearm amino acid release decreased during prolonged fasting even though alanine retained a prominent interorgan role.\nModel: Human balance measurements during prolonged fasting.\nLimitations: Not a recommendation for prolonged fasting, nor evidence for a fixed whole-body alanine flux.\nEvidence access: Primary abstract\nAlanine: key role in gluconeogenesis. · 1970 · https://pubmed.ncbi.nlm.nih.gov/5411169/ · DOI 10.1126/science.167.3920.1003","model_system":"Human balance measurements during prolonged fasting.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"01c5554c-a8ba-5c86-9b01-a0fa1a886cdb","stable_key":"import-10aa417f-4b03-599f-a453-4aa09edeb27c","title":"L-Alanine: carbon, nitrogen, protein synthesis and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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