{"id":"0d9437e5-193a-5723-8b0f-8c9ed4a418ad","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-trans-slc30a10-hepatic-excretion","predicate":"decreases","statement":"Hepatic Slc30a10 deficiency impaired biliary manganese excretion in mice despite only minimal manganese excess.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"9ea3b63b-f774-58ae-8902-1c9aeb9cbb51","mechanism_event_label":"The liver exporter supplied biliary clearance, while other routes limited whole-body accumulation.","subject":{"id":"1301c026-0678-50c1-b77d-63cb81eb49d0","slug":"mouse-hepatocyte-slc30a10-knockout","display_name":"Mouse hepatocyte-specific Slc30a10 knockout genotype","entity_type_key":"gene"},"object":{"id":"9ad3810c-66f4-50a7-a484-6a8c928ea825","slug":"biliary-manganese-excretion","display_name":"Biliary manganese excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9ea3b63b-f774-58ae-8902-1c9aeb9cbb51","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-trans-slc30a10-hepatic-excretion-event","event_type":"biochemical_relationship","label":"The liver exporter supplied biliary clearance, while other routes limited whole-body accumulation.","description":"Hepatic Slc30a10 deficiency impaired biliary manganese excretion in mice despite only minimal manganese excess.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a8082b11-c484-5792-bb81-48e8e699cbe4","slug":"manganese-ion","display_name":"Mn2+","entity_type_key":"ion"},"role":"transported_substrate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3241bcc4-1a56-525d-b130-53d562ea34ce","slug":"mouse-slc30a10","display_name":"Mouse manganese exporter Slc30a10","entity_type_key":"protein"},"role":"affected_transporter","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1301c026-0678-50c1-b77d-63cb81eb49d0","slug":"mouse-hepatocyte-slc30a10-knockout","display_name":"Mouse hepatocyte-specific Slc30a10 knockout genotype","entity_type_key":"gene"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9ad3810c-66f4-50a7-a484-6a8c928ea825","slug":"biliary-manganese-excretion","display_name":"Biliary manganese excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Whole-body and tissue-specific Slc30a10 knockout mice","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Liver-specific Slc30a10 deficiency versus controls.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Minimal systemic excess does not negate the measured biliary transport defect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Manganese research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The liver exporter supplied biliary clearance, while other routes limited whole-body accumulation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mn-trans-31527311] Manganese transporter Slc30a10 controls physiological manganese excretion and toxicity. 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