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unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Retinoid/ISX control of a shared intestinal transporter affects vitamin E status.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Figure 7","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Isx, Bco1, Bco2 and Scarb1 mouse mutants; promoter binding and controlled diets.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Females; ten weeks of AIN93G with 75 IU vitamin E/kg, with or without 50 mg zeaxanthin/kg.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Accumulation is not a clinical benefit; compound mutants had a larger effect than Isx single mutants.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"outcome","value_text":"Isx-deficient mice had higher hepatic alpha-tocopherol; the Isx/Bco2 double mutant showed about twice wild-type levels.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Disrupting vitamin A feedback also changed vitamin E accumulation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[va-widjajaadhi-2015] A genetic dissection of intestinal fat-soluble vitamin and carotenoid absorption (2015). https://pmc.ncbi.nlm.nih.gov/articles/PMC4424956/ DOI: 10.1093/hmg/ddv072","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Jejunum and liver","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"ea13947f-f566-5988-b7fb-ce1bc1155e0a","evidence_kind":"source_excerpt","locator":"Lines 302-315","start_line":302,"end_line":315,"excerpt":"### va-isx-loss-tocopherol\nIsx-deficient mice had higher hepatic alpha-tocopherol; the Isx/Bco2 double mutant showed about twice wild-type levels.\nCondition category: machinery_impairment\nnutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Disrupting vitamin A feedback also changed vitamin E accumulation.\norganism: Mus musculus\ntissue_or_cell_type: Jejunum and liver\nexperimental_model: Isx, Bco1, Bco2 and Scarb1 mouse mutants; promoter binding and controlled diets.\nlimitations: Accumulation is not a clinical benefit; compound mutants had a larger effect than Isx single mutants.\nexposure: Females; ten weeks of AIN93G with 75 IU vitamin E/kg, with or without 50 mg zeaxanthin/kg.\noutcome: Isx-deficient mice had higher hepatic alpha-tocopherol; the Isx/Bco2 double mutant showed about twice wild-type levels.\nevidence_location: Figure 7\ncross_nutrient: Retinoid/ISX control of a shared intestinal transporter affects vitamin E status.\n[va-widjajaadhi-2015] A genetic dissection of intestinal fat-soluble vitamin and carotenoid absorption (2015). https://pmc.ncbi.nlm.nih.gov/articles/PMC4424956/ DOI: 10.1093/hmg/ddv072","model_system":"Isx, Bco1, Bco2 and Scarb1 mouse mutants; 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Study references: [va-widjajaadhi-2015] A genetic dissection of intestinal fat-soluble vitamin and carotenoid absorption (2015). https://pmc.ncbi.nlm.nih.gov/articles/PMC4424956/ DOI: 10.1093/hmg/ddv072","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0c5474e2-be48-547b-b287-9c07a59c9ff1","stable_key":"import-dff9f743-3766-5f20-a71e-d6d2bd5bfb6f","title":"Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b217224b262abbd77d6a0c8c9beefff9c022fae4d31e2a5273915d769b9a6546","revision_id":"61008909-871f-575c-b5e2-21542689ea3c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}