{"id":"0c4475ac-e97e-5cc1-9dd1-8386a43dd7a3","stable_key":"16c35a72-8162-5bb1-ae01-45331b8b42d0:moringa-human-acute-insulin","predicate":"increases","statement":"In ten healthy adults, a single 4 g dose of Moringa leaf powder increased insulin AUC and the insulin-to-glucose AUC ratio by 74% compared with the no-Moringa baseline.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"570deebd-072e-5fc7-b498-cd91a26389b0","mechanism_event_label":"In ten healthy adults, a single 4 g dose of Moringa leaf powder increased insulin AUC and the insulin-to-glucose AUC ratio by 74% compared with the no-Moringa baseline.","subject":{"id":"994f4608-74f6-55d1-b36b-f9284fce9960","slug":"moringa-leaf-powder","display_name":"Moringa dry leaf powder","entity_type_key":"botanical"},"object":{"id":"4369a743-883d-5bb6-a0b0-edd41b31f7f3","slug":"glucose-challenge-insulin-auc","display_name":"Plasma insulin response to glucose challenge","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"570deebd-072e-5fc7-b498-cd91a26389b0","stable_key":"16c35a72-8162-5bb1-ae01-45331b8b42d0:moringa-human-acute-insulin-event","event_type":"observed_relationship","label":"In ten healthy adults, a single 4 g dose of Moringa leaf powder increased insulin AUC and the insulin-to-glucose AUC ratio by 74% compared with the no-Moringa baseline.","description":"In ten healthy adults, a single 4 g dose of Moringa leaf powder increased insulin AUC and the insulin-to-glucose AUC ratio by 74% compared with the no-Moringa baseline.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"994f4608-74f6-55d1-b36b-f9284fce9960","slug":"moringa-leaf-powder","display_name":"Moringa dry leaf powder","entity_type_key":"botanical"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4369a743-883d-5bb6-a0b0-edd41b31f7f3","slug":"glucose-challenge-insulin-auc","display_name":"Plasma insulin response to glucose challenge","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Single 0, 1, 2 and 4 g leaf-powder doses separated by two weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Six hours","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ten healthy adults in an escalating-dose crossover study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The small nonrandomized dose sequence in healthy volunteers does not establish chronic glycemic benefit or an effect in diabetes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Moringa oleifera chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"moringa","display_name":"Moringa oleifera","entity_type_key":"botanical"}},{"dimension":"organism","value_text":"Ten healthy adults in an escalating-dose crossover study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"In ten healthy adults, a single 4 g dose of Moringa leaf powder increased insulin AUC and the insulin-to-glucose AUC ratio by 74% compared with the no-Moringa baseline.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Moringa Oleifera Leaf Increases Insulin Secretion after Single Dose Administration: A Preliminary Study in Healthy Subjects. (2016). https://pubmed.ncbi.nlm.nih.gov/27276742/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Plasma insulin and insulin/glucose AUC","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"564c0f32-bc2d-5535-8d67-42ec60b51566","evidence_kind":"source_excerpt","locator":"Lines 112-121","start_line":112,"end_line":121,"excerpt":"## moringa-human-acute-insulin\nIn ten healthy adults, a single 4 g dose of Moringa leaf powder increased insulin AUC and the insulin-to-glucose AUC ratio by 74% compared with the no-Moringa baseline.\nModel/species: Ten healthy adults in an escalating-dose crossover study\nTissue/system: Plasma insulin and insulin/glucose AUC\nExposure: Single 0, 1, 2 and 4 g leaf-powder doses separated by two weeks\nRoute: Oral\nDuration: Six hours\nLimits: The small nonrandomized dose sequence in healthy volunteers does not establish chronic glycemic benefit or an effect in diabetes.\nPrimary reference: Moringa Oleifera Leaf Increases Insulin Secretion after Single Dose Administration: A Preliminary Study in Healthy Subjects. (2016). https://pubmed.ncbi.nlm.nih.gov/27276742/\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Ten healthy adults in an escalating-dose crossover study","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2752e9b3-e4b9-55fe-be07-944204cca4b8","stable_key":"import-16c35a72-8162-5bb1-ae01-45331b8b42d0","title":"Moringa oleifera: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. 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