{"id":"0c18de85-70f0-5ab7-9b86-a9e3d7aac4c0","stable_key":"e37461ea-ea5d-5e2c-8091-138305f6dd70:l-aspartate-infant-first-pass","predicate":"undergoes_first_pass_uptake","statement":"Dual-isotope tracing in eight enterally fed preterm infants measured splanchnic first-pass aspartate uptake of 77 ± 15%.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9045e952-5f72-5384-bbb1-e3aabfd0472e","mechanism_event_label":"Much of the ingested amino acid was handled before reaching the wider circulation.","subject":{"id":"0a0923d3-72b7-5d6a-bf3a-5a7a3071a09b","slug":"l-aspartate","display_name":"L-Aspartate","entity_type_key":"small_molecule"},"object":{"id":"bc8519d3-5081-53ee-83d7-15b345c59355","slug":"preterm-infant-splanchnic-aspartate-uptake","display_name":"Splanchnic first-pass aspartate uptake in preterm infants","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9045e952-5f72-5384-bbb1-e3aabfd0472e","stable_key":"e37461ea-ea5d-5e2c-8091-138305f6dd70:l-aspartate-infant-first-pass-event","event_type":"observed_relationship","label":"Much of the ingested amino acid was handled before reaching the wider circulation.","description":"Dual-isotope tracing in eight enterally fed preterm infants measured splanchnic first-pass aspartate uptake of 77 ± 15%.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0a0923d3-72b7-5d6a-bf3a-5a7a3071a09b","slug":"l-aspartate","display_name":"L-Aspartate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"bc8519d3-5081-53ee-83d7-15b345c59355","slug":"preterm-infant-splanchnic-aspartate-uptake","display_name":"Splanchnic first-pass aspartate uptake in preterm infants","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Eight infants, gestational age 26–34 weeks; enteral and intravenous stable-isotope tracer protocol.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Do not substitute the paper title’s almost all for 100%, or extrapolate this percentage to healthy adults.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-aspartate","display_name":"L-Aspartate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Much of the ingested amino acid was handled before reaching the wider circulation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Almost all enteral aspartate is taken up in first-pass metabolism in enterally fed preterm infants. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20022677/ · DOI 10.1016/j.clnu.2009.11.008","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"41f3f2d2-bb20-5809-827b-56cc847c9b15","evidence_kind":"source_excerpt","locator":"Lines 18-24","start_line":18,"end_line":24,"excerpt":"## l-aspartate-infant-first-pass\nMuch of the ingested amino acid was handled before reaching the wider circulation.\nDual-isotope tracing in eight enterally fed preterm infants measured splanchnic first-pass aspartate uptake of 77 ± 15%.\nModel: Eight infants, gestational age 26–34 weeks; enteral and intravenous stable-isotope tracer protocol.\nLimitations: Do not substitute the paper title’s almost all for 100%, or extrapolate this percentage to healthy adults.\nEvidence access: Primary abstract\nAlmost all enteral aspartate is taken up in first-pass metabolism in enterally fed preterm infants. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20022677/ · DOI 10.1016/j.clnu.2009.11.008","model_system":"Eight infants, gestational age 26–34 weeks; enteral and intravenous stable-isotope tracer protocol.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"67970dcb-34e0-5b0a-8c86-d8c3cc183444","stable_key":"import-e37461ea-ea5d-5e2c-8091-138305f6dd70","title":"L-Aspartate: redox transfer, nitrogen partitioning and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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