{"id":"0bd537e4-a3aa-5fc3-9574-66f4b687d827","stable_key":"research:selenov-loss-reduces-ogt-activity","predicate":"loss-decreases-activity","statement":"Selenov loss reduced adipose OGT activity in mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"literature_reviewed:direct_experimental","direction":"negative","is_public":true,"mechanism_event_id":"82e74c0f-c10f-50db-b6ef-072adca02cf6","mechanism_event_label":"Mouse fat tissue had less OGT activity after SELENOV loss.","subject":{"id":"916cbbc3-1543-564d-85a5-fd6b7c209bef","slug":"selenov","display_name":"SELENOV","entity_type_key":"protein"},"object":{"id":"e0d1556b-a4d5-51d7-bad7-ab7a0cfc9ddf","slug":"ogt","display_name":"OGT","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"82e74c0f-c10f-50db-b6ef-072adca02cf6","stable_key":"research:selenov-loss-reduces-ogt-activity","event_type":"genetic-perturbation","label":"Mouse fat tissue had less OGT activity after SELENOV loss.","description":"Selenov loss reduced adipose OGT activity in mice.","status":"active","compartment":{"slug":"adipose-tissue","display_name":"Adipose tissue"},"participants":[{"entity":{"id":"916cbbc3-1543-564d-85a5-fd6b7c209bef","slug":"selenov","display_name":"SELENOV","entity_type_key":"protein"},"role":"perturbed-protein","stoichiometry":null,"state_label":"deleted","sequence_order":0,"notes":""},{"entity":{"id":"e0d1556b-a4d5-51d7-bad7-ab7a0cfc9ddf","slug":"ogt","display_name":"OGT","entity_type_key":"protein"},"role":"measured-enzyme","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cell_type","value_text":"adipose tissue","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Selenov knockout","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Do not equate this perturbation with human dietary deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"mouse","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3360f43c-2526-58a5-bba0-89d6cdf630e7","evidence_kind":"curated_literature_summary","locator":"lines 822-832","start_line":822,"end_line":832,"excerpt":"## selenov-loss-reduces-ogt-activity\n\nMouse fat tissue had less OGT activity after SELENOV loss.\n\nSelenov loss reduced adipose OGT activity in mice.\n\nOrganism: mouse\nCell type: adipose tissue\nExperimental model: Selenov knockout\nLimitations: Do not equate this perturbation with human dietary deficiency.\nPrimary reference: [Loss of Selenov predisposes mice to extra fat accumulation and attenuated energy expenditure](https://pubmed.ncbi.nlm.nih.gov/34167027/)","model_system":"Selenov knockout","directness":"author_interpretation","verification_status":"secondary_verified","notes":"Curated summary; inspect the linked primary papers for original methods and results.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4f892f13-06ea-5199-a33c-a703f35c80ae","stable_key":"selenium-research-2026-09-17","title":"Selenium: literature corrections and mechanism additions","document_type":"curated_literature_review","citation_label":"Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually","file_path":"","sha256":"0b818b10c1c7120e5caf7f4d4019d7bd025d745692e424f515d3ef903c9ab7f3","revision_id":"80984e03-5f0f-5877-8094-afef7637444e","review_status":"secondary_verified","notes":"Secondary curated summaries of primary experiments, with explicit models and limitations. Not archived primary full text."}}],"relations":[],"conflicts":[],"corrections":[],"research":{"topic":"protein-glycosylation","plain_language":"Mouse fat tissue had less OGT activity after SELENOV loss.","evidence_scope":"direct_experimental","papers":[{"key":"chen-2021-selenov-ogt","title":"Loss of Selenov predisposes mice to extra fat accumulation and attenuated energy expenditure","url":"https://pubmed.ncbi.nlm.nih.gov/34167027/","doi":"10.1016/j.redox.2021.102048","year":2021,"model":"Selenov-knockout mice and protein-interaction assays","summary":"Connects SELENOV with OGT binding and altered O-GlcNAcylation in adipose tissue."}]}}