{"id":"0b46b575-bddb-5ba0-a27d-cadcaef20646","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-tollip-gate","predicate":"required_in_model_for","statement":"Tollip silencing impaired EGCG inhibition of TLR4 signaling.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7318a1aa-f87c-5cdd-b58a-6858ab524b85","mechanism_event_label":"The anti-inflammatory response depended on Tollip.","subject":{"id":"0c3e9bd5-2972-5f55-a80c-fd5d7d40ca5c","slug":"tollip-family","display_name":"Toll-interacting protein family / Tollip","entity_type_key":"protein_family"},"object":{"id":"b52d0179-9778-50aa-98c8-a20bbea79fca","slug":"tlr4-signaling","display_name":"TLR4 downstream inflammatory signaling","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7318a1aa-f87c-5cdd-b58a-6858ab524b85","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-tollip-gate-event","event_type":"observed_relationship","label":"The anti-inflammatory response depended on Tollip.","description":"Tollip silencing impaired EGCG inhibition of TLR4 signaling.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0c3e9bd5-2972-5f55-a80c-fd5d7d40ca5c","slug":"tollip-family","display_name":"Toll-interacting protein family / Tollip","entity_type_key":"protein_family"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b52d0179-9778-50aa-98c8-a20bbea79fca","slug":"tlr4-signaling","display_name":"TLR4 downstream inflammatory signaling","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e96aad69-74fb-55c6-8378-7d5c281003eb","slug":"lipopolysaccharide","display_name":"Lipopolysaccharide","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Macrophage LPS-response experiments, EGCG 1 micromolar; organism not assigned from abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Family nodes preserve the unresolved species. This is not evidence of treating systemic human inflammation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The anti-inflammatory response depended on Tollip.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"TLR4 signaling inhibitory pathway induced by green tea polyphenol epigallocatechin-3-gallate through 67-kDa laminin receptor. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20511545/ · DOI 10.4049/jimmunol.0903742","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"5ad166e8-27cc-5283-9a2f-39093a654764","evidence_kind":"source_excerpt","locator":"Lines 116-122","start_line":116,"end_line":122,"excerpt":"## egcg-tollip-gate\nThe anti-inflammatory response depended on Tollip.\nTollip silencing impaired EGCG inhibition of TLR4 signaling.\nModel: Macrophage LPS-response experiments, EGCG 1 micromolar; organism not assigned from abstract.\nLimitations: Family nodes preserve the unresolved species. This is not evidence of treating systemic human inflammation.\nEvidence access: primary abstract.\nTLR4 signaling inhibitory pathway induced by green tea polyphenol epigallocatechin-3-gallate through 67-kDa laminin receptor. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20511545/ · DOI 10.4049/jimmunol.0903742","model_system":"Macrophage LPS-response experiments, EGCG 1 micromolar; organism not assigned from abstract.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}