{"id":"0b1fa9cf-57da-561f-beba-7300db0e31b7","stable_key":"182336c6-ed36-5ec6-8a09-25c31096262e:dim-bap-total","predicate":"reduces_recovered","statement":"DIM and Brussels-sprout interventions reduced total plasma-recovered BaP-related radiocarbon by 56-67% relative to the non-intervention condition.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"07b0f6fd-9679-55dc-9895-ad8c8e003d87","mechanism_event_label":"Parent compound and combined metabolites were distinct measurements.","subject":{"id":"6009bdd4-f1b5-5867-b5c3-cdf7c9645cd0","slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"},"object":{"id":"0be4039f-bd17-543a-aacd-27864cbb22ca","slug":"total-bap-related-plasma-radioactivity","display_name":"Total BaP-related plasma radiocarbon signal","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"07b0f6fd-9679-55dc-9895-ad8c8e003d87","stable_key":"182336c6-ed36-5ec6-8a09-25c31096262e:dim-bap-total-event","event_type":"observed_intervention","label":"Parent compound and combined metabolites were distinct measurements.","description":"DIM and Brussels-sprout interventions reduced total plasma-recovered BaP-related radiocarbon by 56-67% relative to the non-intervention condition.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6009bdd4-f1b5-5867-b5c3-cdf7c9645cd0","slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0be4039f-bd17-543a-aacd-27864cbb22ca","slug":"total-bap-related-plasma-radioactivity","display_name":"Total BaP-related plasma radiocarbon signal","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/dim-research/36642108.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"93b6510deeea8915ef7bd506c9b7d1d83b8d4b417f3e8194cbb9b33a89233384\", \"start_char\": 0, \"end_char\": 1801, \"text_sha256\": \"93b6510deeea8915ef7bd506c9b7d1d83b8d4b417f3e8194cbb9b33a89233384\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Within-person human dietary intervention and radiotracer microdose","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Seven days of BR-DIM or Brussels sprouts before 50-ng radiolabeled BaP","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Microdose kinetics with large individual variation. Lower plasma radiocarbon does not establish less DNA damage or reduced human cancer risk.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Small adult volunteer cohort","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Parent compound and combined metabolites were distinct measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[dim-p36642108] Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or Brussels sprouts. (2023). https://pubmed.ncbi.nlm.nih.gov/36642108/ DOI: 10.1016/j.taap.2023.116377","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Benzo[a]pyrene absorption and metabolism","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e6d75ea7-62c4-5086-9e80-c511026a7e45","evidence_kind":"source_excerpt","locator":"Lines 1221-1232","start_line":1221,"end_line":1232,"excerpt":"### dim-bap-total\nDIM and Brussels-sprout interventions reduced total plasma-recovered BaP-related radiocarbon by 56-67% relative to the non-intervention condition.\nCondition category: normal\nnutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Parent compound and combined metabolites were distinct measurements.\norganism: Small adult volunteer cohort\ntissue_or_cell_type: Benzo[a]pyrene absorption and metabolism\nexperimental_model: Within-person human dietary intervention and radiotracer microdose\nlimitations: Microdose kinetics with large individual variation. Lower plasma radiocarbon does not establish less DNA damage or reduced human cancer risk.\nexposure: Seven days of BR-DIM or Brussels sprouts before 50-ng radiolabeled BaP\nevidence_span: {\"source_cache\": \"artifacts/dim-research/36642108.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"93b6510deeea8915ef7bd506c9b7d1d83b8d4b417f3e8194cbb9b33a89233384\", \"start_char\": 0, \"end_char\": 1801, \"text_sha256\": \"93b6510deeea8915ef7bd506c9b7d1d83b8d4b417f3e8194cbb9b33a89233384\"}\n[dim-p36642108] Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or Brussels sprouts. 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