{"id":"0b0c9881-160d-5c65-8853-ec4191d69d44","stable_key":"7484635e-cc8f-5cd6-a978-6dc5775a7db5:berberine-adenoma-followup","predicate":"prior_assignment_associated_with_less","statement":"Post-treatment follow-up reported adenoma recurrence of 34.7% after prior berberine assignment versus 52.1% after prior placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"52291907-de8f-55cf-8ab1-0490719d86f0","mechanism_event_label":"The long follow-up is useful, while its observational phase and shared participants remain explicit.","subject":{"id":"7bbe0633-b2f1-510f-adc0-3c4d0ddad05d","slug":"berberine","display_name":"Berberine","entity_type_key":"small_molecule"},"object":{"id":"4c47991c-d43e-542e-b061-839709a6c320","slug":"colorectal-adenoma-recurrence","display_name":"Colorectal adenoma recurrence","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"52291907-de8f-55cf-8ab1-0490719d86f0","stable_key":"7484635e-cc8f-5cd6-a978-6dc5775a7db5:berberine-adenoma-followup-event","event_type":"observed_intervention","label":"The long follow-up is useful, while its observational phase and shared participants remain explicit.","description":"Post-treatment follow-up reported adenoma recurrence of 34.7% after prior berberine assignment versus 52.1% after prior placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7bbe0633-b2f1-510f-adc0-3c4d0ddad05d","slug":"berberine","display_name":"Berberine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4c47991c-d43e-542e-b061-839709a6c320","slug":"colorectal-adenoma-recurrence","display_name":"Colorectal adenoma recurrence","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/berberine-research/40795846.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1df2fd3eb5e8daef204f50dac917098b8c4be324d6e5d3a85b7aa3a9385ffc24\", \"start_char\": 0, \"end_char\": 983, \"text_sha256\": \"1df2fd3eb5e8daef204f50dac917098b8c4be324d6e5d3a85b7aa3a9385ffc24\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Retrospective post-treatment follow-up of the previous randomized trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Up to six years after treatment cessation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This is follow-up of the same original trial, not an independent randomized trial; post-trial selection and surveillance can affect estimates.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Berberine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"berberine","display_name":"Berberine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"781 recruited from the earlier cohort; 648 underwent follow-up colonoscopy","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The long follow-up is useful, while its observational phase and shared participants remain explicit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[berberine-p40795846] Berberine for preventing colorectal adenoma recurrence and neoplasm occurrence: 6-Year follow-up of a randomized clinical trial. (2025). https://pubmed.ncbi.nlm.nih.gov/40795846/ DOI: 10.1016/j.xcrm.2025.102293","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Long-term adenoma recurrence","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3ce092b5-9154-53a0-9691-02db40f58643","evidence_kind":"source_excerpt","locator":"Lines 1325-1336","start_line":1325,"end_line":1336,"excerpt":"### berberine-adenoma-followup\nPost-treatment follow-up reported adenoma recurrence of 34.7% after prior berberine assignment versus 52.1% after prior placebo.\nCondition category: normal\nnutrient_topic: Berberine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The long follow-up is useful, while its observational phase and shared participants remain explicit.\norganism: 781 recruited from the earlier cohort; 648 underwent follow-up colonoscopy\ntissue_or_cell_type: Long-term adenoma recurrence\nexperimental_model: Retrospective post-treatment follow-up of the previous randomized trial\nlimitations: This is follow-up of the same original trial, not an independent randomized trial; post-trial selection and surveillance can affect estimates.\nexposure: Up to six years after treatment cessation\nevidence_span: {\"source_cache\": \"artifacts/berberine-research/40795846.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1df2fd3eb5e8daef204f50dac917098b8c4be324d6e5d3a85b7aa3a9385ffc24\", \"start_char\": 0, \"end_char\": 983, \"text_sha256\": \"1df2fd3eb5e8daef204f50dac917098b8c4be324d6e5d3a85b7aa3a9385ffc24\"}\n[berberine-p40795846] Berberine for preventing colorectal adenoma recurrence and neoplasm occurrence: 6-Year follow-up of a randomized clinical trial. (2025). https://pubmed.ncbi.nlm.nih.gov/40795846/ DOI: 10.1016/j.xcrm.2025.102293","model_system":"Retrospective post-treatment follow-up of the previous randomized trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [berberine-p40795846] Berberine for preventing colorectal adenoma recurrence and neoplasm occurrence: 6-Year follow-up of a randomized clinical trial. (2025). https://pubmed.ncbi.nlm.nih.gov/40795846/ DOI: 10.1016/j.xcrm.2025.102293","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"9bb61e1d-e5cf-5b05-a9ca-409291f7a313","stable_key":"import-7484635e-cc8f-5cd6-a978-6dc5775a7db5","title":"Berberine: metabolism, nutrient connections and drug interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"2f376a035ae79c93e62e2ea4a8d5385643bf16553f108d12b6a80c89e6d41f4c","revision_id":"2a099429-1c4a-55be-aa2c-0565d08bda80","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}