{"id":"0ac849be-8c09-5ac8-af62-c3b09a340272","stable_key":"44eaeae5-557a-552b-8998-884f30462e2a:sulforaphane-autism-younger-null","predicate":"did_not_significantly_improve","statement":"The study found no significant clinical improvement on ADOS-2, ABC or SRS-2 in the younger-child cohort.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"eb1040d7-5b63-5d4b-a994-588e1755ec26","mechanism_event_label":"Later testing did not reproduce a clear benefit in this population.","subject":{"id":"67e70215-70c4-546a-84b4-0819fac0b326","slug":"sulforaphane","display_name":"Sulforaphane / SFN, stereochemistry specified per study","entity_type_key":"small_molecule"},"object":{"id":"d2f3b02b-9d42-57c1-8618-7f9a0ca8c1ba","slug":"autism-ados2-score","display_name":"ADOS-2 assessment score","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"eb1040d7-5b63-5d4b-a994-588e1755ec26","stable_key":"44eaeae5-557a-552b-8998-884f30462e2a:sulforaphane-autism-younger-null-event","event_type":"biochemical_relationship","label":"Later testing did not reproduce a clear benefit in this population.","description":"The study found no significant clinical improvement on ADOS-2, ABC or SRS-2 in the younger-child cohort.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"67e70215-70c4-546a-84b4-0819fac0b326","slug":"sulforaphane","display_name":"Sulforaphane / SFN, stereochemistry specified per study","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d2f3b02b-9d42-57c1-8618-7f9a0ca8c1ba","slug":"autism-ados2-score","display_name":"ADOS-2 assessment score","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/sulforaphane-research/36771424.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"b571349cae03a080b09b387fa132d9f534133caef7a187be028370a9db48636e\", \"start_char\": 0, \"end_char\": 1410, \"text_sha256\": \"b571349cae03a080b09b387fa132d9f534133caef7a187be028370a9db48636e\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Prospective randomized double-blind placebo-controlled study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Assessments at baseline, 18 and 36 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small sample with attrition; different age/formulation/endpoint context is retained rather than automatically classified as a contradiction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sulforaphane research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sulforaphane","display_name":"Sulforaphane / SFN, stereochemistry specified per study","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human, children aged 3-7; 40 randomized and 28 completed","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Later testing did not reproduce a clear benefit in this population.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[sulforaphane-p36771424] Sulforaphane Treatment in Children with Autism: A Prospective Randomized Double-Blind Study. (2023). https://pubmed.ncbi.nlm.nih.gov/36771424/ DOI: 10.3390/nu15030718","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"ABC, SRS-2 and ADOS-2","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3f25db04-6d85-5793-a3f5-e1a08fe55a6f","evidence_kind":"source_excerpt","locator":"Lines 1386-1397","start_line":1386,"end_line":1397,"excerpt":"### sulforaphane-autism-younger-null\nThe study found no significant clinical improvement on ADOS-2, ABC or SRS-2 in the younger-child cohort.\nCondition category: normal\nnutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Later testing did not reproduce a clear benefit in this population.\norganism: Human, children aged 3-7; 40 randomized and 28 completed\ntissue_or_cell_type: ABC, SRS-2 and ADOS-2\nexperimental_model: Prospective randomized double-blind placebo-controlled study\nlimitations: Small sample with attrition; different age/formulation/endpoint context is retained rather than automatically classified as a contradiction.\nexposure: Assessments at baseline, 18 and 36 weeks\nevidence_span: {\"source_cache\": \"artifacts/sulforaphane-research/36771424.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"b571349cae03a080b09b387fa132d9f534133caef7a187be028370a9db48636e\", \"start_char\": 0, \"end_char\": 1410, \"text_sha256\": \"b571349cae03a080b09b387fa132d9f534133caef7a187be028370a9db48636e\"}\n[sulforaphane-p36771424] Sulforaphane Treatment in Children with Autism: A Prospective Randomized Double-Blind Study. 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