{"id":"0a4046a0-7a7c-5ade-bd4d-beaba6714e57","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-muscle-glut4","predicate":"increases_membrane_translocation","statement":"Fourteen days of injected myricetin improved insulin-stimulated GLUT4 translocation and downstream signaling in fructose-fed rat soleus muscle.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7944c992-d1d6-5fa6-8187-e2c2520a70ee","mechanism_event_label":"The muscle response involved transporter relocation.","subject":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"object":{"id":"b355feba-1bd3-55d6-9f12-54b9fbadfd58","slug":"rat-slc2a4","display_name":"Rat glucose transporter 4 / Slc2a4","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"7944c992-d1d6-5fa6-8187-e2c2520a70ee","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-muscle-glut4-event","event_type":"observed_relationship","label":"The muscle response involved transporter relocation.","description":"Fourteen days of injected myricetin improved insulin-stimulated GLUT4 translocation and downstream signaling in fructose-fed rat soleus muscle.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b355feba-1bd3-55d6-9f12-54b9fbadfd58","slug":"rat-slc2a4","display_name":"Rat glucose transporter 4 / Slc2a4","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"3c225e65-2cb3-5cd9-a26d-cce9cac32e8a","slug":"rat-oprm1","display_name":"Rat mu-opioid receptor / Oprm1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rats; 1 mg/kg per injection, three injections daily, 14 days.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Different tissue and exposure from isolated adipocytes; not a scientific contradiction or evidence of oral human efficacy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The muscle response involved transporter relocation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Myricetin Ameliorates Defective Post-Receptor Insulin Signaling via β-Endorphin Signaling in the Skeletal Muscles of Fructose-Fed Rats. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21785619/ · DOI 10.1093/ecam/neq017","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9e89b7f9-f113-5597-a313-48e7541eeb93","evidence_kind":"source_excerpt","locator":"Lines 500-506","start_line":500,"end_line":506,"excerpt":"## myricetin-muscle-glut4\nThe muscle response involved transporter relocation.\nFourteen days of injected myricetin improved insulin-stimulated GLUT4 translocation and downstream signaling in fructose-fed rat soleus muscle.\nModel: Rats; 1 mg/kg per injection, three injections daily, 14 days.\nLimitations: Different tissue and exposure from isolated adipocytes; not a scientific contradiction or evidence of oral human efficacy.\nEvidence access: Primary abstract\nMyricetin Ameliorates Defective Post-Receptor Insulin Signaling via β-Endorphin Signaling in the Skeletal Muscles of Fructose-Fed Rats. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21785619/ · DOI 10.1093/ecam/neq017","model_system":"Rats; 1 mg/kg per injection, three injections daily, 14 days.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"58045cd9-3b27-5469-bb4b-e1c6a9bdca34","stable_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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