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Mouse EAE and cultured T cells do not establish that salt causes human multiple sclerosis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sodium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sodium","display_name":"Sodium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human and mouse T cells; mouse disease model","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Salt conditions can change immune-cell differentiation in an experimental setting.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[sodium-p23467095] Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. (2013). https://pubmed.ncbi.nlm.nih.gov/23467095/ DOI: 10.1038/nature11868","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"T-helper cells and experimental CNS autoimmunity","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0897d4de-664f-5a7c-9d34-53345ded8c26","evidence_kind":"source_excerpt","locator":"Lines 486-497","start_line":486,"end_line":497,"excerpt":"### sodium-salt-th17\nIncreased NaCl enhanced cytokine-induced TH17 differentiation in human and mouse T-cell cultures.\nCondition category: normal\nnutrient_topic: Sodium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Salt conditions can change immune-cell differentiation in an experimental setting.\norganism: Human and mouse T cells; mouse disease model\ntissue_or_cell_type: T-helper cells and experimental CNS autoimmunity\nexperimental_model: Cytokine-driven T-cell culture, gene silencing/inhibition and experimental autoimmune encephalomyelitis\nlimitations: NaCl exposure includes both ions and osmotic context. Mouse EAE and cultured T cells do not establish that salt causes human multiple sclerosis.\nexposure: Increased NaCl in culture or high-salt mouse diet\nevidence_span: {\"source_cache\": \"artifacts/sodium-research/23467095.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d16bb4b4becde85238492e01054f360aeaf57ea90015cba99459cd155fa4251f\", \"start_char\": 0, \"end_char\": 1913, \"text_sha256\": \"d16bb4b4becde85238492e01054f360aeaf57ea90015cba99459cd155fa4251f\"}\n[sodium-p23467095] Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. 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