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(2023). https://pubmed.ncbi.nlm.nih.gov/36658222/ DOI: 10.1038/s41556-022-01071-y","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Mitochondria and plasma membrane","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"25a1e25e-3ca0-58c1-a243-ac65e14305b2","evidence_kind":"source_excerpt","locator":"Lines 502-513","start_line":502,"end_line":513,"excerpt":"### coq10-stard7-pc\nA CoQ variant competed with phosphatidylcholine for binding to purified STARD7.\nCondition category: normal\nnutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Choline-containing membrane lipid and a CoQ analogue shared access to a transport protein.\norganism: Mammalian cell models\ntissue_or_cell_type: Mitochondria and plasma membrane\nexperimental_model: Protein processing, localization, transport and cell-growth experiments\nlimitations: Purified-protein binding with a CoQ variant; not demonstrated dietary choline competition with CoQ10 absorption.\nexposure: PARL processing and compartment-specific STARD7 expression\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/36658222.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8cd5c486ecb31ad03ea06a817eb5bc56e60abdfa8ae8d50a46502974be2898ce\", \"start_char\": 0, \"end_char\": 1410, \"text_sha256\": \"8cd5c486ecb31ad03ea06a817eb5bc56e60abdfa8ae8d50a46502974be2898ce\"}\n[coq10-p36658222] Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7. 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