{"id":"0932818b-8eec-529f-994b-6bc831d09a18","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-ugt-substrate-selectivity","predicate":"inhibits_glucuronidation","statement":"Trans-resveratrol inhibited SN-38 glucuronidation in human enzyme experiments (Ki 6.2 ± 2.1 micromolar), while bilirubin glucuronidation showed no major change.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"83aef6f5-6f4c-5542-999b-e5fbbf863297","mechanism_event_label":"The interaction depends on the enzyme substrate.","subject":{"id":"61e08499-3296-56f9-9656-e7263b876637","slug":"trans-resveratrol","display_name":"trans-Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"3d4aa140-fdc4-5a4e-b15c-13035f218f11","slug":"sn-38","display_name":"SN-38","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"83aef6f5-6f4c-5542-999b-e5fbbf863297","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-ugt-substrate-selectivity-event","event_type":"observed_relationship","label":"The interaction depends on the enzyme substrate.","description":"Trans-resveratrol inhibited SN-38 glucuronidation in human enzyme experiments (Ki 6.2 ± 2.1 micromolar), while bilirubin glucuronidation showed no major change.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"61e08499-3296-56f9-9656-e7263b876637","slug":"trans-resveratrol","display_name":"trans-Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3d4aa140-fdc4-5a4e-b15c-13035f218f11","slug":"sn-38","display_name":"SN-38","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"a54855e7-1ba5-5d14-8c14-70f06248ae5a","slug":"ugt1a1","display_name":"Human UDP-glucuronosyltransferase 1A1 / UGT1A1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human microsomal/recombinant assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not demonstrated irinotecan toxicity or a clinical dose-adjustment rule.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The interaction depends on the enzyme substrate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Glucuronidation of trans-resveratrol by human liver and intestinal microsomes and UGT isoforms. · 2006 · https://pubmed.ncbi.nlm.nih.gov/16597364/ · DOI 10.1211/jpp.58.4.0006","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"36b6f8c3-ae10-55c2-9e3b-213adc611ce8","evidence_kind":"source_excerpt","locator":"Lines 46-52","start_line":46,"end_line":52,"excerpt":"## resveratrol-ugt-substrate-selectivity\nThe interaction depends on the enzyme substrate.\nTrans-resveratrol inhibited SN-38 glucuronidation in human enzyme experiments (Ki 6.2 ± 2.1 micromolar), while bilirubin glucuronidation showed no major change.\nModel: Human microsomal/recombinant assays.\nLimitations: Not demonstrated irinotecan toxicity or a clinical dose-adjustment rule.\nEvidence access: Primary abstract\nGlucuronidation of trans-resveratrol by human liver and intestinal microsomes and UGT isoforms. · 2006 · https://pubmed.ncbi.nlm.nih.gov/16597364/ · DOI 10.1211/jpp.58.4.0006","model_system":"Human microsomal/recombinant assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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