{"id":"08ef7d23-7d06-5336-9ae2-0404dc580338","stable_key":"6a5c5b4f-d859-5f43-ab2f-45c594a570ae:surface-dele1-hri","predicate":"has_contextual_experimental_effect","statement":"Surface-retained DELE1 engaged HRI during iron deficiency.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"cba75227-4112-549d-97f4-96861821e064","mechanism_event_label":"surface dele1 hri","subject":{"id":"ade89048-a4cf-5aad-9932-5eddfe958964","slug":"human-dele1-import-arrest","display_name":"Full-length human DELE1 retained at mitochondrial surface during iron chelation","entity_type_key":"protein_state"},"object":{"id":"785c0cc6-0e06-5145-ad20-12b847ae12de","slug":"human-eif2ak1","display_name":"Human HRI / EIF2AK1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"cba75227-4112-549d-97f4-96861821e064","stable_key":"6a5c5b4f-d859-5f43-ab2f-45c594a570ae:surface-dele1-hri","event_type":"experimental_result","label":"surface dele1 hri","description":"Surface-retained DELE1 engaged HRI during iron deficiency.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ade89048-a4cf-5aad-9932-5eddfe958964","slug":"human-dele1-import-arrest","display_name":"Full-length human DELE1 retained at mitochondrial surface during iron chelation","entity_type_key":"protein_state"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"785c0cc6-0e06-5145-ad20-12b847ae12de","slug":"human-eif2ak1","display_name":"Human HRI / EIF2AK1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"access_level","value_text":"selected_indexed_full_text_passages","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_cache","value_text":"artifacts/discovery-research/round2-sources/primary-mechanism-passages.json; SHA256 81c0207494f0b2a22fd0af0d70528a5114dfd74367dd99f967f4ada68c53e8c3","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human cultured cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Iron chelation; panel-specific dose/time unresolved","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Selected indexed primary full-text passages reviewed; supplements not independently inspected in this round. These records do not demonstrate iron-chelation rescue of SLC25A39 loss, clinical benefit, or transfer to pulmonary endothelium.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Human cultured cells; mouse xenograft host only for colonization endpoint","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Surface-retained DELE1 engaged HRI during iron deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_locator","value_text":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10329284/ Figures 5–6; TPR accessibility experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"https://doi.org/10.1016/j.molcel.2023.05.031","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8ba708b8-0477-5f4b-9bdd-8c782b9cb0e8","evidence_kind":"source_excerpt","locator":"Lines 67-76","start_line":67,"end_line":76,"excerpt":"Surface-retained DELE1 engaged HRI during iron deficiency.\nprimary_references: https://doi.org/10.1016/j.molcel.2023.05.031\nprimary_locator: https://pmc.ncbi.nlm.nih.gov/articles/PMC10329284/ Figures 5–6; TPR accessibility experiments\nevidence_cache: artifacts/discovery-research/round2-sources/primary-mechanism-passages.json; SHA256 81c0207494f0b2a22fd0af0d70528a5114dfd74367dd99f967f4ada68c53e8c3\naccess_level: selected_indexed_full_text_passages\nexperimental_model: Human cultured cells\norganism: Human cultured cells; mouse xenograft host only for colonization endpoint\nexposure: Iron chelation; panel-specific dose/time unresolved\nlimitations: Selected indexed primary full-text passages reviewed; supplements not independently inspected in this round. These records do not demonstrate iron-chelation rescue of SLC25A39 loss, clinical benefit, or transfer to pulmonary endothelium.\nplain_language: Surface-retained DELE1 engaged HRI during iron deficiency.","model_system":"Human cultured cells","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Authored paraphrase; primary location and access limits retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"046f00ee-97ea-559c-b25f-7f73427fd72d","stable_key":"import-6a5c5b4f-d859-5f43-ab2f-45c594a570ae","title":"DELE1 bridge: iron sensing and mitochondrial-glutathione-dependent stress signaling","document_type":"imported_text","citation_label":"Targeted primary-literature curation; selected indexed full-text passages, 2026-09-20.","file_path":"","sha256":"dbf79243751a179cadaaa833295cc4bdd0e617117e657c11eed25d7877267503","revision_id":"0218c622-6d40-5429-b03f-e5d2e1e67684","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}