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The peripheral site of action is inferred from route comparison, not from direct measurement at the nerve ending.\nexposure: M8-B intravenously, intrathecally or intracerebroventricularly, at constant or changing ambient temperature\nevidence_span: {\"source_cache\": \"artifacts/cold-research/22323721.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c0ead3b0097eaa75bf74d806e7f40bc61da4275cdd0af92735be9cad681ed3f0\", \"start_char\": 0, \"end_char\": 1784, \"text_sha256\": \"c0ead3b0097eaa75bf74d806e7f40bc61da4275cdd0af92735be9cad681ed3f0\"}\n[cold-p22323721] Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. 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