{"id":"082618e6-4810-5d31-b6ba-8ec1d936ab6f","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-rat-redox-ketones","predicate":"reduces","statement":"In perfused fasted-rat liver, fisetin reduced ketogenesis and the beta-hydroxybutyrate/acetoacetate ratio.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"cfc239ff-fba6-5993-9dff-a829e0610036","mechanism_event_label":"The metabolic redox state shifted toward oxidation.","subject":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"object":{"id":"b2d3d9f7-0e0c-523d-a212-7b894b2951d7","slug":"rat-liver-ketone-redox-ratio","display_name":"Rat liver beta-hydroxybutyrate/acetoacetate ratio","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cfc239ff-fba6-5993-9dff-a829e0610036","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-rat-redox-ketones-event","event_type":"observed_relationship","label":"The metabolic redox state shifted toward oxidation.","description":"In perfused fasted-rat liver, fisetin reduced ketogenesis and the beta-hydroxybutyrate/acetoacetate ratio.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b2d3d9f7-0e0c-523d-a212-7b894b2951d7","slug":"rat-liver-ketone-redox-ratio","display_name":"Rat liver beta-hydroxybutyrate/acetoacetate ratio","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9fbf2e03-16a9-5ca7-965c-0bfc07ca24da","slug":"nadh","display_name":"NADH","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"283ed24b-06a1-50aa-9281-df3bac6ce37e","slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat liver and mitochondrial experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The ketone ratio is a redox proxy, not a direct measurement of all NAD pools.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The metabolic redox state shifted toward oxidation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Prooxidant activity of fisetin: effects on energy metabolism in the rat liver. · 2011 · https://pubmed.ncbi.nlm.nih.gov/20957679/ · DOI 10.1002/jbt.20367","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2ffface4-ab65-5407-b54a-9163277b228a","evidence_kind":"source_excerpt","locator":"Lines 344-350","start_line":344,"end_line":350,"excerpt":"## fisetin-rat-redox-ketones\nThe metabolic redox state shifted toward oxidation.\nIn perfused fasted-rat liver, fisetin reduced ketogenesis and the beta-hydroxybutyrate/acetoacetate ratio.\nModel: Rat liver and mitochondrial experiments.\nLimitations: The ketone ratio is a redox proxy, not a direct measurement of all NAD pools.\nEvidence access: Primary abstract\nProoxidant activity of fisetin: effects on energy metabolism in the rat liver. · 2011 · https://pubmed.ncbi.nlm.nih.gov/20957679/ · DOI 10.1002/jbt.20367","model_system":"Rat liver and mitochondrial experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1108bfff-6504-5152-a51f-ff3d7c27c282","stable_key":"import-74ef5bba-ee14-531c-b1bf-d1f297c56bb6","title":"Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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