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topical membership is not evidence of a direct dietary effect.\nplain_language: The cytokine environment determines which T-cell differentiation program RA modifies.\norganism: Mus musculus\ntissue_or_cell_type: Naive T-cell cultures\nexperimental_model: Mouse naive T-cell differentiation under TGF-beta and inflammatory cytokine conditions.\nlimitations: New lineage induction differs from established intestinal Th17 effector function.\nevidence_locator: Abstract\nexposure: RA with IL-6/TGF-beta\n[va-mucida-2007] Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid (2007). https://pubmed.ncbi.nlm.nih.gov/17569825/ DOI: 10.1126/science.1145697","model_system":"Mouse naive T-cell differentiation under TGF-beta and inflammatory cytokine conditions.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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