{"id":"07dd3439-a601-581e-b472-5dcf788c8572","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-gastric-mitochondria","predicate":"preserves","statement":"Astaxanthin attenuated the fall in mitochondrial membrane potential and ATP in H. pylori-challenged AGS cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"57657077-d5ea-5456-865f-566fb780db67","mechanism_event_label":"Energy-related measurements were preserved during the challenge.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"8d14dbc9-3cf3-5783-b034-39214d936952","slug":"human-astaxanthin-gastric-mitochondria","display_name":"Mitochondrial potential and ATP in H. pylori-challenged AGS cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"57657077-d5ea-5456-865f-566fb780db67","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-gastric-mitochondria-event","event_type":"observed_relationship","label":"Energy-related measurements were preserved during the challenge.","description":"Astaxanthin attenuated the fall in mitochondrial membrane potential and ATP in H. pylori-challenged AGS cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8d14dbc9-3cf3-5783-b034-39214d936952","slug":"human-astaxanthin-gastric-mitochondria","display_name":"Mitochondrial potential and ATP in H. pylori-challenged AGS cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human AGS cell experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Protection in a challenge assay does not establish direct electron donation to the respiratory chain.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Energy-related measurements were preserved during the challenge.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Astaxanthin Inhibits Mitochondrial Dysfunction and Interleukin-8 Expression in Helicobacter pylori-Infected Gastric Epithelial Cells. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30231525/ · DOI 10.3390/nu10091320","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"073cb576-3768-57fb-9226-03dfc65c2ea4","evidence_kind":"source_excerpt","locator":"Lines 318-324","start_line":318,"end_line":324,"excerpt":"## astaxanthin-gastric-mitochondria\nEnergy-related measurements were preserved during the challenge.\nAstaxanthin attenuated the fall in mitochondrial membrane potential and ATP in H. pylori-challenged AGS cells.\nModel: Human AGS cell experiments.\nLimitations: Protection in a challenge assay does not establish direct electron donation to the respiratory chain.\nEvidence access: Primary abstract\nAstaxanthin Inhibits Mitochondrial Dysfunction and Interleukin-8 Expression in Helicobacter pylori-Infected Gastric Epithelial Cells. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30231525/ · DOI 10.3390/nu10091320","model_system":"Human AGS cell experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"98640e32f62e6c0387578165342ad21b3d2325701fcfdbb5c48886c783040e5e","revision_id":"a82757ce-1feb-582c-a5fc-f7de36308f1f","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}