{"id":"07bbd66c-5b56-58f7-82ea-b9119cc23ad6","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-parl-stard7","predicate":"processes","statement":"PARL cleavage supported the dual mitochondrial and cytosolic localization of STARD7.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3280fcc4-d326-5151-905b-d4dbb025e031","mechanism_event_label":"Processing one transport protein helps decide where CoQ can go.","subject":{"id":"bfa4e6ce-abbd-556e-9bf9-4779f098c5bf","slug":"parl","display_name":"Human mitochondrial rhomboid protease / PARL","entity_type_key":"protein"},"object":{"id":"afef27d7-c2cd-5d51-8f1f-330e16b21f48","slug":"stard7","display_name":"Human STARD7 lipid-transfer protein","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"3280fcc4-d326-5151-905b-d4dbb025e031","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-parl-stard7-event","event_type":"biochemical_relationship","label":"Processing one transport protein helps decide where CoQ can go.","description":"PARL cleavage supported the dual mitochondrial and cytosolic localization of STARD7.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bfa4e6ce-abbd-556e-9bf9-4779f098c5bf","slug":"parl","display_name":"Human mitochondrial rhomboid protease / PARL","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"afef27d7-c2cd-5d51-8f1f-330e16b21f48","slug":"stard7","display_name":"Human STARD7 lipid-transfer protein","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/coq10-research/36658222.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8cd5c486ecb31ad03ea06a817eb5bc56e60abdfa8ae8d50a46502974be2898ce\", \"start_char\": 0, \"end_char\": 1410, \"text_sha256\": \"8cd5c486ecb31ad03ea06a817eb5bc56e60abdfa8ae8d50a46502974be2898ce\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Protein processing, localization, transport and cell-growth experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"PARL processing and compartment-specific STARD7 expression","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Intracellular distribution mechanism; increasing oral dose does not prove delivery to a particular organelle.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mammalian cell models","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Processing one transport protein helps decide where CoQ can go.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[coq10-p36658222] Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7. 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