{"id":"076d98eb-5fc1-5ca0-9163-d2f7efdf2b18","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-aved-residual-deficits","predicate":"does_not_reverse","statement":"Absent reflexes and posterior-column disturbances persisted despite normalization of serum vitamin E during AVED supplementation.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"139a1f18-319b-5481-96d3-75b990322449","mechanism_event_label":"Correcting the blood level did not reverse every established nerve deficit.","subject":{"id":"e67a0437-6900-5f53-8b03-c0a7ad6d92b6","slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"},"object":{"id":"b0061aac-5314-531e-9024-21c1f142e59b","slug":"aved-neurological-deficits","display_name":"AVED reflex and posterior-column deficits","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"139a1f18-319b-5481-96d3-75b990322449","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-aved-residual-deficits-event","event_type":"observed_intervention","label":"Correcting the blood level did not reverse every established nerve deficit.","description":"Absent reflexes and posterior-column disturbances persisted despite normalization of serum vitamin E during AVED supplementation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8793fb03-2ab4-5f16-bdbe-c18ca395d7d7","slug":"ttpa","display_name":"Human alpha-tocopherol transfer protein","entity_type_key":"protein"},"role":"affected_delivery_machinery","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e67a0437-6900-5f53-8b03-c0a7ad6d92b6","slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b0061aac-5314-531e-9024-21c1f142e59b","slug":"aved-neurological-deficits","display_name":"AVED reflex and posterior-column deficits","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Uncontrolled one-year supplementation study; 24 genetically investigated AVED patients","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Vitamin E 800 mg/day for one year; formulation stereochemistry not specified in the retrieved abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small uncontrolled genetic-disease cohort; no inference of complete reversal, a general population dose or isolated dietary deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin E research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Correcting the blood level did not reverse every established nerve deficit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[e-clin-aved2001] Effect of vitamin E supplementation in patients with ataxia with vitamin E deficiency. 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