{"id":"072fab73-84af-5fb6-a3e9-3f6e562df53e","stable_key":"548ab9d6-3a9b-5bed-879c-17d03813b636:b2-blood-vitamer-response","predicate":"changed_plasma_and_redcell_markers","statement":"In 46 randomized older adults, supplementation increased plasma riboflavin by 83% and erythrocyte FMN by 87%; measured markers other than plasma FAD responded significantly.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"724cf506-afc9-543a-866b-f994f1a0f62f","mechanism_event_label":"Blood B2 comes in several forms, and they do not all respond equally to intake.","subject":{"id":"86eb1eee-a8d1-539c-8c17-0911f69b6f1b","slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"},"object":{"id":"e11125ef-6b45-542e-8517-1d8b299ad203","slug":"plasma-riboflavin-concentration","display_name":"Plasma riboflavin concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"724cf506-afc9-543a-866b-f994f1a0f62f","stable_key":"548ab9d6-3a9b-5bed-879c-17d03813b636:b2-blood-vitamer-response-event","event_type":"observed_intervention","label":"Blood B2 comes in several forms, and they do not all respond equally to intake.","description":"In 46 randomized older adults, supplementation increased plasma riboflavin by 83% and erythrocyte FMN by 87%; 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unverified.","entity":null}],"evidence":[{"id":"bbe81158-608c-5efe-94b2-fe15a22ae5bc","evidence_kind":"source_excerpt","locator":"Lines 1617-1627","start_line":1617,"end_line":1627,"excerpt":"### b2-blood-vitamer-response\nIn 46 randomized older adults, supplementation increased plasma riboflavin by 83% and erythrocyte FMN by 87%; measured markers other than plasma FAD responded significantly.\nCondition category: biomarker_context\nnutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Blood B2 comes in several forms, and they do not all respond equally to intake.\norganism: Homo sapiens\ntissue_or_cell_type: Human clinical setting\nexperimental_model: 124 healthy older adults, mean age 69; 46 with EGRAC >=1.20 randomized equally to riboflavin or placebo.\nlimitations: Older adults selected by EGRAC; percentages are study responses, not diagnostic thresholds or predicted individual gains.\nexposure: 1.6 mg/day riboflavin versus placebo for 12 weeks; HPLC plasma/red-cell vitamer measurements.\n[b2-hustad2002] Riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma and erythrocytes at baseline and after low-dose riboflavin supplementation (2002). https://pubmed.ncbi.nlm.nih.gov/12194936/ DOI: 10.1093/clinchem/48.9.1571","model_system":"124 healthy older adults, mean age 69; 46 with EGRAC >=1.20 randomized equally to riboflavin or placebo.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b2-hustad2002] Riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma and erythrocytes at baseline and after low-dose riboflavin supplementation (2002). https://pubmed.ncbi.nlm.nih.gov/12194936/ DOI: 10.1093/clinchem/48.9.1571","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4f7c9578-82bf-5e2d-b5c4-72a79fb4f6af","stable_key":"import-548ab9d6-3a9b-5bed-879c-17d03813b636","title":"Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"680cb6bc8249877f2410f551807f10d390fdd719014137d7414ba3420e29228d","revision_id":"7a61e299-908d-5372-860b-99ed190f9d7a","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}