{"id":"06c8496c-d55a-5b41-819c-e64e2db411f5","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:bacterial-cada-decarboxylation","predicate":"decarboxylates","statement":"E. coli CadA converts lysine to cadaverine and CO2 while consuming a proton during acid stress.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ff420b7a-245e-5f11-9085-b398d0a8195d","mechanism_event_label":"Some bacteria use lysine to buffer acidic conditions.","subject":{"id":"b65b03de-45c6-5ed2-94de-e772bdd42a3c","slug":"e-coli-cada","display_name":"E. coli CadA","entity_type_key":"protein"},"object":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"ff420b7a-245e-5f11-9085-b398d0a8195d","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:bacterial-cada-decarboxylation-event","event_type":"biochemical_relationship","label":"Some bacteria use lysine to buffer acidic conditions.","description":"E. coli CadA converts lysine to cadaverine and CO2 while consuming a proton during acid stress.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b65b03de-45c6-5ed2-94de-e772bdd42a3c","slug":"e-coli-cada","display_name":"E. coli CadA","entity_type_key":"protein"},"role":"enzyme","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"role":"substrate","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"082dc221-9d81-5de3-8b73-0508a2ce0859","slug":"cadaverine","display_name":"Cadaverine","entity_type_key":"small_molecule"},"role":"product","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"966f14e5-c82f-5535-ad89-bfcc0adb2232","slug":"carbon-dioxide","display_name":"Carbon dioxide","entity_type_key":"small_molecule"},"role":"coproduct","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"1ed0233a-3d10-58b3-abda-8ad04545c495","slug":"proton","display_name":"Proton","entity_type_key":"ion"},"role":"cosubstrate","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"6b656ff5-9532-5da4-8eea-8ca163a48649","slug":"pyridoxal-phosphate","display_name":"PLP","entity_type_key":"small_molecule"},"role":"cofactor","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"E. coli inducible lysine decarboxylase structural and acid-stress experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Bacterial pathway. Cadaverine exposure or health effects in a human cannot be inferred from this culture mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Escherichia coli","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Some bacteria use lysine to buffer acidic conditions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cada-2011] Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase (2011). https://pubmed.ncbi.nlm.nih.gov/21278708/ DOI: 10.1038/emboj.2011.5","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Not specified as a whole tissue; see experimental model.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d7be584e-3f2e-5080-a450-a57d9355d004","evidence_kind":"source_excerpt","locator":"Lines 618-626","start_line":618,"end_line":626,"excerpt":"### bacterial-cada-decarboxylation\nE. coli CadA converts lysine to cadaverine and CO2 while consuming a proton during acid stress.\nPlain language: Some bacteria use lysine to buffer acidic conditions.\nCondition category: normal\norganism: Escherichia coli\ntissue_or_cell_type: Not specified as a whole tissue; see experimental model.\nexperimental_model: E. coli inducible lysine decarboxylase structural and acid-stress experiments.\nlimitations: Bacterial pathway. Cadaverine exposure or health effects in a human cannot be inferred from this culture mechanism.\n[cada-2011] Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase (2011). https://pubmed.ncbi.nlm.nih.gov/21278708/ DOI: 10.1038/emboj.2011.5","model_system":"E. coli inducible lysine decarboxylase structural and acid-stress experiments.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact quote from the accompanying curation document, not from publisher text. Original study references: [cada-2011] Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase (2011). https://pubmed.ncbi.nlm.nih.gov/21278708/ DOI: 10.1038/emboj.2011.5","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7633bde7-dcc9-5086-91c6-a45eb96857f3","stable_key":"import-c3df3634-4c3a-5099-a5d9-e4f6344c1084","title":"L-Lysine: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"93998d47c21525409ba82f1c82ededf2893dff15fbe61c7deffc175b0e298e97","revision_id":"3897e31f-6624-59e1-a053-8a81b7361632","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}