{"id":"06b8f207-eace-5e6f-953d-782723706af4","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-gldc-formate-bypass","predicate":"rescues_tested","statement":"Formate treatment normalized folate profiles, restored embryonic growth and prevented neural-tube defects in the tested Gldc-deficient mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"69c9dbe5-d262-5cad-9993-73e3258f9c02","mechanism_event_label":"A downstream carbon donor bypassed part of the missing pathway.","subject":{"id":"1fc1fa42-fcb5-5983-9a31-114703dc64c4","slug":"formate","display_name":"Formate","entity_type_key":"small_molecule"},"object":{"id":"bdcc34ea-ab4e-54f7-8df4-0546e784c2f3","slug":"mouse-gldc-embryonic-development","display_name":"Embryonic development in Gldc-deficient mice","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"69c9dbe5-d262-5cad-9993-73e3258f9c02","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-gldc-formate-bypass-event","event_type":"observed_relationship","label":"A downstream carbon donor bypassed part of the missing pathway.","description":"Formate treatment normalized folate profiles, restored embryonic growth and prevented neural-tube defects in the tested Gldc-deficient mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1fc1fa42-fcb5-5983-9a31-114703dc64c4","slug":"formate","display_name":"Formate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"bdcc34ea-ab4e-54f7-8df4-0546e784c2f3","slug":"mouse-gldc-embryonic-development","display_name":"Embryonic development in Gldc-deficient mice","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7d9397c2-a65e-5a90-b3dc-05b284eb1794","slug":"mouse-gldc","display_name":"Mouse glycine decarboxylase / Gldc","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"e176a266-711e-5469-89da-3fb2d3f244ad","slug":"folate","display_name":"Folate (vitamin B9)","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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