{"id":"0693392a-daa0-5a6d-bf03-30e985759ab4","stable_key":"88eb7407-f147-558b-889b-0c89c4e0aa4a:spermidine-atp13a2-failure","predicate":"loss_impairs","statement":"Loss or disease-associated impairment of ATP13A2 reduced export function and worsened high-polyamine lysosomal injury.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c211834b-e07d-5d81-b985-2f2e26972f73","mechanism_event_label":"A transport defect can make extra polyamine harmful.","subject":{"id":"409f2bb7-f510-56e1-8f03-a8b9587af3df","slug":"atp13a2","display_name":"Human ATP13A2 / PARK9","entity_type_key":"protein"},"object":{"id":"48bc0bab-aace-567c-96ac-a1ece2793677","slug":"human-lysosomal-polyamine-export","display_name":"Human lysosome-to-cytosol polyamine export","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c211834b-e07d-5d81-b985-2f2e26972f73","stable_key":"88eb7407-f147-558b-889b-0c89c4e0aa4a:spermidine-atp13a2-failure-event","event_type":"observed_relationship","label":"A transport defect can make extra polyamine harmful.","description":"Loss or disease-associated impairment of ATP13A2 reduced export function and worsened high-polyamine lysosomal injury.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"409f2bb7-f510-56e1-8f03-a8b9587af3df","slug":"atp13a2","display_name":"Human ATP13A2 / PARK9","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"48bc0bab-aace-567c-96ac-a1ece2793677","slug":"human-lysosomal-polyamine-export","display_name":"Human lysosome-to-cytosol polyamine export","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7014993c-468f-5c6b-ab04-80c87f9dfd9f","slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human transporter/cell experiments; neuronal and nematode validation in the paper.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Do not infer that dietary spermidine treats ATP13A2 disease; high-exposure findings retain their context.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Spermidine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A transport defect can make extra polyamine harmful.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"ATP13A2 deficiency disrupts lysosomal polyamine export. · 2020 · https://pubmed.ncbi.nlm.nih.gov/31996848/ · DOI 10.1038/s41586-020-1968-7","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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