{"id":"0685ba94-33e6-541f-ac95-95225d0de2a9","stable_key":"b26c9d01-98fd-50d3-8f39-44db46961ee5:acetate-corrosive-injury","predicate":"causes","statement":"A 39-year-old woman who drank one tablespoon of white vinegar to soften a crab shell stuck in her throat was found on endoscopy to have inflammation of the oropharynx and second-degree caustic injury of the oesophagus extending to the cardia, with an uneventful recovery.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"4c6959e2-a9ab-551d-bde5-8a443a8943e5","mechanism_event_label":"One tablespoon, swallowed neat, burned the throat and the length of the gullet.","subject":{"id":"236303ab-c590-5e01-bace-9f2cf05fa6fa","slug":"acetic-acid","display_name":"Acetic acid","entity_type_key":"chemical_species"},"object":{"id":"718f9130-b5b4-5e3d-b901-37df629f04e3","slug":"corrosive-oesophageal-injury","display_name":"Caustic injury of the oropharynx and oesophagus","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4c6959e2-a9ab-551d-bde5-8a443a8943e5","stable_key":"b26c9d01-98fd-50d3-8f39-44db46961ee5:acetate-corrosive-injury-event","event_type":"observed_intervention","label":"One tablespoon, swallowed neat, burned the throat and the length of the gullet.","description":"A 39-year-old woman who drank one tablespoon of white vinegar to soften a crab shell stuck in her throat was found on endoscopy to have inflammation of the oropharynx and second-degree caustic injury of the oesophagus extending to the cardia, with an uneventful recovery.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3fab36ca-d4b5-5f87-b101-3e4157008f14","slug":"native-vinegar","display_name":"Native vinegar supplying free acetic acid","entity_type_key":"chemical_species"},"role":"ingested_form","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"236303ab-c590-5e01-bace-9f2cf05fa6fa","slug":"acetic-acid","display_name":"Acetic acid","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"718f9130-b5b4-5e3d-b901-37df629f04e3","slug":"corrosive-oesophageal-injury","display_name":"Caustic injury of the oropharynx and oesophagus","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/acetate-research/12376715.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"028d663eb0bf09494f45ded6c6045d6fc40a2ac3c0ae1a3a6dab5fafef985e55\", \"start_char\": 0, \"end_char\": 482, \"text_sha256\": \"028d663eb0bf09494f45ded6c6045d6fc40a2ac3c0ae1a3a6dab5fafef985e55\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Single clinical case report with endoscopy","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"One tablespoon of white vinegar swallowed to dislodge a crab shell from the throat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A single case. It establishes that the same compound is corrosive at the concentration sold for cooking, which none of the dietary studies address.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Acetic acid research collection; topical membership is not evidence of a direct clinical effect, and the ingested acid is recorded separately from the circulating acetate anion.","comparator":null,"unit":null,"notes":"","entity":{"slug":"acetic-acid","display_name":"Acetic acid","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"One tablespoon, swallowed neat, burned the throat and the length of the gullet.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[acetate-p12376715] Corrosive oesophageal injury following vinegar ingestion. (2002). https://pubmed.ncbi.nlm.nih.gov/12376715/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Oropharynx and oesophagus","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"27b8f169-68d8-56d9-aa11-e4a41608de0b","evidence_kind":"source_excerpt","locator":"Lines 212-223","start_line":212,"end_line":223,"excerpt":"### acetate-corrosive-injury\nA 39-year-old woman who drank one tablespoon of white vinegar to soften a crab shell stuck in her throat was found on endoscopy to have inflammation of the oropharynx and second-degree caustic injury of the oesophagus extending to the cardia, with an uneventful recovery.\nCondition category: normal\nnutrient_topic: Acetic acid research collection; topical membership is not evidence of a direct clinical effect, and the ingested acid is recorded separately from the circulating acetate anion.\nplain_language: One tablespoon, swallowed neat, burned the throat and the length of the gullet.\norganism: Human\ntissue_or_cell_type: Oropharynx and oesophagus\nexperimental_model: Single clinical case report with endoscopy\nlimitations: A single case. It establishes that the same compound is corrosive at the concentration sold for cooking, which none of the dietary studies address.\nexposure: One tablespoon of white vinegar swallowed to dislodge a crab shell from the throat\nevidence_span: {\"source_cache\": \"artifacts/acetate-research/12376715.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"028d663eb0bf09494f45ded6c6045d6fc40a2ac3c0ae1a3a6dab5fafef985e55\", \"start_char\": 0, \"end_char\": 482, \"text_sha256\": \"028d663eb0bf09494f45ded6c6045d6fc40a2ac3c0ae1a3a6dab5fafef985e55\"}\n[acetate-p12376715] Corrosive oesophageal injury following vinegar ingestion. (2002). https://pubmed.ncbi.nlm.nih.gov/12376715/","model_system":"Single clinical case report with endoscopy","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [acetate-p12376715] Corrosive oesophageal injury following vinegar ingestion. (2002). https://pubmed.ncbi.nlm.nih.gov/12376715/","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"8356baaf-173c-5549-80cd-bbbb2007ffb5","stable_key":"import-b26c9d01-98fd-50d3-8f39-44db46961ee5","title":"Acetic acid: the ingested acid, the receptors acetate binds, the acetyl-CoA it becomes, and the acetyl groups that reach histones (2026-09-21)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"1441d249b16db25c0d488407e5cc881222acffc2f16af88cb3197d9d5697bccc","revision_id":"9bfeb605-f589-5e99-84b9-e56968a3bc1f","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}