{"id":"065abc2a-dd05-5d93-a90b-1f31f32bc1e9","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-relax-creatine","predicate":"reduces","statement":"Four days of creatine shortened stimulated-muscle relaxation time by about 5%.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"e36f0432-4133-5bc6-b3b3-02101a761977","mechanism_event_label":"Creatine altered a muscle-relaxation measurement.","subject":{"id":"9f5df558-ed3d-5cda-b5ca-0f90f7aa6a8c","slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"},"object":{"id":"948a9644-3011-5f27-9b89-6a4d11d978ac","slug":"quadriceps-relaxation-time","display_name":"Electrically evoked quadriceps relaxation time","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e36f0432-4133-5bc6-b3b3-02101a761977","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-relax-creatine-event","event_type":"observed_relationship","label":"Creatine altered a muscle-relaxation measurement.","description":"Four days of creatine shortened stimulated-muscle relaxation time by about 5%.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9f5df558-ed3d-5cda-b5ca-0f90f7aa6a8c","slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"948a9644-3011-5f27-9b89-6a4d11d978ac","slug":"quadriceps-relaxation-time","display_name":"Electrically evoked quadriceps relaxation time","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c081984a-e118-582f-ac46-6a767f8f0bf2","slug":"phosphocreatine","display_name":"Phosphocreatine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ten men; double-blind crossover; creatine 20 g/day; electrically stimulated quadriceps.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No direct measurement of calcium-pump mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Caffeine collection; salts, coffee, species and coexposure contexts retain their identities.","comparator":null,"unit":null,"notes":"","entity":{"slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Creatine altered a muscle-relaxation measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Opposite actions of caffeine and creatine on muscle relaxation time in humans. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11796658/ · DOI 10.1152/japplphysiol.00255.2001","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d7aa19fc-25f2-5eb7-b97f-e34987c1b39f","evidence_kind":"source_excerpt","locator":"Lines 460-466","start_line":460,"end_line":466,"excerpt":"## caf-relax-creatine\nCreatine altered a muscle-relaxation measurement.\nFour days of creatine shortened stimulated-muscle relaxation time by about 5%.\nModel: Ten men; double-blind crossover; creatine 20 g/day; electrically stimulated quadriceps.\nLimitations: No direct measurement of calcium-pump mediation.\nEvidence access: Primary abstract\nOpposite actions of caffeine and creatine on muscle relaxation time in humans. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11796658/ · DOI 10.1152/japplphysiol.00255.2001","model_system":"Ten men; double-blind crossover; creatine 20 g/day; electrically stimulated quadriceps.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access stated with the claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"40a654db-878c-5471-bc6c-88f4f52599c0","stable_key":"import-ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6","title":"Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"780d73d4abd45a0284d2cc0c646dbe8432ae347362891a4b98a19a61341a7325","revision_id":"f36ffb0a-d6df-522f-b783-5e30214b9e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}