{"id":"0658502a-5946-5800-9c9a-7407db6ce252","stable_key":"a8baf7e9-80e4-5d8c-adec-9a63e84d2f21:l-cysteine-pdac-coa-rescue","predicate":"rescues_tested","statement":"Adding CoA prevented ferroptosis induced by imidazole ketone erastin in the reported PDAC cell experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a7d1d24a-d513-59be-ba2f-d21a695b7e4c","mechanism_event_label":"Restoring a downstream metabolite bypassed part of an upstream block in culture.","subject":{"id":"4faa6456-aff8-59eb-9e3f-3326a436e401","slug":"coenzyme-a","display_name":"Coenzyme A","entity_type_key":"small_molecule"},"object":{"id":"2010e387-e521-56f3-84da-361550cc53f3","slug":"human-pdac-ferroptosis","display_name":"Ferroptosis in human pancreatic cancer models","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a7d1d24a-d513-59be-ba2f-d21a695b7e4c","stable_key":"a8baf7e9-80e4-5d8c-adec-9a63e84d2f21:l-cysteine-pdac-coa-rescue-event","event_type":"observed_relationship","label":"Restoring a downstream metabolite bypassed part of an upstream block in culture.","description":"Adding CoA prevented ferroptosis induced by imidazole ketone erastin in the reported PDAC cell experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4faa6456-aff8-59eb-9e3f-3326a436e401","slug":"coenzyme-a","display_name":"Coenzyme A","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2010e387-e521-56f3-84da-361550cc53f3","slug":"human-pdac-ferroptosis","display_name":"Ferroptosis in human pancreatic cancer models","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ca899f13-50ad-55e5-ab99-329ae0038c74","slug":"l-cysteine","display_name":"L-Cysteine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"aac19cc3-1b68-5ca3-a896-f61184f7320a","slug":"slc7a11","display_name":"SLC7A11","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"cdd84f4d-3e8f-502a-a8c5-19672cc5346f","slug":"cystine","display_name":"Cystine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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