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Abstract-only extraction; do not generalize to all hearts or propose NNT inhibition clinically.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Niacin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"niacin","display_name":"Niacin (vitamin B3)","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Under this high-workload condition Nnt used up NADPH instead of supplying it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[nnt-reverse-2015] Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure. (2015). https://pubmed.ncbi.nlm.nih.gov/26256392/ DOI: 10.1016/j.cmet.2015.07.008","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Heart","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"61588349-3249-575f-830a-e329ef7e6a9c","evidence_kind":"source_excerpt","locator":"Lines 1016-1027","start_line":1016,"end_line":1027,"excerpt":"### b3-redox-nnt-reversal\nIn the cardiac pathological-workload study, reverse-mode Nnt consumed NADPH while supporting NADH and ATP production.\nCondition category: machinery_impairment\nnutrient_topic: Niacin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Under this high-workload condition Nnt used up NADPH instead of supplying it.\norganism: Mus musculus\ntissue_or_cell_type: Heart\nexperimental_model: Mouse cardiac pressure-overload / pathological-demand experiments\nlimitations: Context-dependent reversal, not genetic kinase failure or dietary niacin deficiency. Abstract-only extraction; do not generalize to all hearts or propose NNT inhibition clinically.\nexposure: Pathological cardiac metabolic demand\nevidence_span: {\"source_cache\": \"artifacts/niacin-redox-sources/nnt-reverse-2015.abstract.txt\", \"locator\": \"Indexed abstract, pathological workload results\", \"start_char\": 373, \"end_char\": 1028, \"file_sha256\": \"88e6510d357946cd087e5af7ca3c9fdfd2ac22f2fb1851dd1164f176c5e39ce4\", \"text_sha256\": \"a8e2d67ccb1f5f041786aecfb33760602a804017dccfe41c54b34213ea0c6223\"}\n[nnt-reverse-2015] Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure. (2015). https://pubmed.ncbi.nlm.nih.gov/26256392/ DOI: 10.1016/j.cmet.2015.07.008","model_system":"Mouse cardiac pressure-overload / pathological-demand experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [nnt-reverse-2015] Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure. (2015). https://pubmed.ncbi.nlm.nih.gov/26256392/ DOI: 10.1016/j.cmet.2015.07.008","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"a62b7b5b-786a-57e9-85e9-67c6912a5054","stable_key":"import-a9dd23c6-978a-5755-8bd8-f29bd1fe0cda","title":"Niacin: NAD metabolism, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8cac59639322f74812ce12eef338c2f6c385c04cc4af6ab511fc7c972f0c2e6","revision_id":"bec8fc45-12e7-5f75-a814-5d72ed015d01","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}