{"id":"0606c7c3-562c-5d04-b9b6-109a63bbe664","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-acid-variability","predicate":"has_measured_variability_in","statement":"Twelve products labeled 600 mg per capsule contained 0.00–2.30 mg monacolin KA per capsule, alongside variable lactone and total monacolins.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"24efa6c6-d55b-52a5-aae9-74ea6ff685be","mechanism_event_label":"Acid-form content also varied.","subject":{"id":"c099293f-a298-5019-b797-70850e18fce7","slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"},"object":{"id":"bd3bb602-9a12-5d58-8130-538236270e6f","slug":"lovastatin-acid","display_name":"Lovastatin hydroxy acid / monacolin KA","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"24efa6c6-d55b-52a5-aae9-74ea6ff685be","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-acid-variability-event","event_type":"observed_relationship","label":"Acid-form content also varied.","description":"Twelve products labeled 600 mg per capsule contained 0.00–2.30 mg monacolin KA per capsule, alongside variable lactone and total monacolins.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c099293f-a298-5019-b797-70850e18fce7","slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"bd3bb602-9a12-5d58-8130-538236270e6f","slug":"lovastatin-acid","display_name":"Lovastatin hydroxy acid / monacolin KA","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Commercial formulations analyzed in 2006–2008.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Do not infer acid/lactone proportions from the red yeast rice mass on a label.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Acid-form content also varied.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[20975018] Marked variability of monacolin levels in commercial red yeast rice products: buyer beware! · 2010 · https://pubmed.ncbi.nlm.nih.gov/20975018/ · DOI 10.1001/archinternmed.2010.382","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"349495c1-44a0-5a09-87e4-c6b09d9384bb","evidence_kind":"source_excerpt","locator":"Lines 28-34","start_line":28,"end_line":34,"excerpt":"## red-yeast-rice-acid-variability\nAcid-form content also varied.\nTwelve products labeled 600 mg per capsule contained 0.00–2.30 mg monacolin KA per capsule, alongside variable lactone and total monacolins.\nModel: Commercial formulations analyzed in 2006–2008.\nLimitations: Do not infer acid/lactone proportions from the red yeast rice mass on a label.\nEvidence access: Primary abstract\n[20975018] Marked variability of monacolin levels in commercial red yeast rice products: buyer beware! · 2010 · https://pubmed.ncbi.nlm.nih.gov/20975018/ · DOI 10.1001/archinternmed.2010.382","model_system":"Commercial formulations analyzed in 2006–2008.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"261a12bc-3d00-52a4-a5ec-70e174390596","stable_key":"import-4910e17b-aaec-52cd-b9e5-caca85d817ee","title":"Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"271bbcecaaacc76ad4d06718ae592dc6a1b33e3e459adfdd36cbd0ac5f09c0f6","revision_id":"9c30956c-206c-5c49-ae42-81b070088e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}