{"id":"05db9c6d-8c87-51f0-a6ec-259bbfc5644c","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-pregnancy-executive","predicate":"does-not-significantly-improve","statement":"The BRIEF-P global executive score averaged 90.6 versus 91.5; reported difference −0.9 (95% CI −6.8 to 5.0), P=0.74.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"d74fbe7c-e77d-56ea-bb1a-bc75b8b88828","mechanism_event_label":"Executive-function scores did not significantly differ between the trial groups.","subject":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"object":{"id":"71d09870-17d9-5a6f-81e5-78d3dcfb26a7","slug":"child-brief-p-executive-score","display_name":"Child BRIEF-P global executive composite score","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d74fbe7c-e77d-56ea-bb1a-bc75b8b88828","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-pregnancy-executive-event","event_type":"observed_intervention","label":"Executive-function scores did not significantly differ between the trial groups.","description":"The BRIEF-P global executive score averaged 90.6 versus 91.5; reported difference −0.9 (95% CI −6.8 to 5.0), P=0.74.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e0ac6d1-3336-506a-9f69-5838ca1500ed","slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"},"role":"supplemented nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"71d09870-17d9-5a6f-81e5-78d3dcfb26a7","slug":"child-brief-p-executive-score","display_name":"Child BRIEF-P global executive composite score","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary full PDF Methods; Table2 and Fig2; Discussion, pp.853–863.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind placebo-controlled maternal trial in Bangkok and Bangalore; 832 women randomized, 313 children assessed for IQ and 315 for executive function at age 5–6","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"200 micrograms iodine/day as potassium iodide until delivery; mean enrollment 10.7 weeks gestation; baseline median urinary iodine 131 micrograms/L; IQ iodine 159/placebo 154, executive function 159/156.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Mild group-level deficiency with site differences: Thailand deficient and India at low adequacy. Substantial attrition was balanced between groups; measured baseline characteristics were similar in those followed and lost. This does not test preconception treatment or severe deficiency. Reported differences, CIs and mixed-model P values are retained as published.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Executive-function scores did not significantly differ between the trial groups.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iod-clin-gow2017] Effect of iodine supplementation in pregnant women on child neurodevelopment: a randomised, double-blind, placebo-controlled trial. (2017). https://pubmed.ncbi.nlm.nih.gov/29030199/ DOI: 10.1016/s2213-8587(17)30332-7","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Maternal iodine status and child neurodevelopment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"773f799d-0984-5adf-a892-4fa0fcf63e7f","evidence_kind":"source_excerpt","locator":"Lines 1398-1410","start_line":1398,"end_line":1410,"excerpt":"### iod-clin-pregnancy-executive\nThe BRIEF-P global executive score averaged 90.6 versus 91.5; reported difference −0.9 (95% CI −6.8 to 5.0), P=0.74.\nCondition category: nutrient_deficiency\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Executive-function scores did not significantly differ between the trial groups.\norganism: Homo sapiens\ntissue_or_cell_type: Maternal iodine status and child neurodevelopment\nexperimental_model: Randomized double-blind placebo-controlled maternal trial in Bangkok and Bangalore; 832 women randomized, 313 children assessed for IQ and 315 for executive function at age 5–6\nlimitations: Mild group-level deficiency with site differences: Thailand deficient and India at low adequacy. Substantial attrition was balanced between groups; measured baseline characteristics were similar in those followed and lost. This does not test preconception treatment or severe deficiency. Reported differences, CIs and mixed-model P values are retained as published.\nexposure: 200 micrograms iodine/day as potassium iodide until delivery; mean enrollment 10.7 weeks gestation; baseline median urinary iodine 131 micrograms/L; IQ iodine 159/placebo 154, executive function 159/156.\ncross_nutrient: false\nevidence_location: Primary full PDF Methods; Table2 and Fig2; Discussion, pp.853–863.\n[iod-clin-gow2017] Effect of iodine supplementation in pregnant women on child neurodevelopment: a randomised, double-blind, placebo-controlled trial. (2017). https://pubmed.ncbi.nlm.nih.gov/29030199/ DOI: 10.1016/s2213-8587(17)30332-7","model_system":"Randomized double-blind placebo-controlled maternal trial in Bangkok and Bangalore; 832 women randomized, 313 children assessed for IQ and 315 for executive function at age 5–6","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [iod-clin-gow2017] Effect of iodine supplementation in pregnant women on child neurodevelopment: a randomised, double-blind, placebo-controlled trial. 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