{"id":"05b57828-ada4-5c6b-a495-82665f56a7b9","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-magnesium-low-melatonin","predicate":"dietary_deficiency_reduces","statement":"Mean plasma melatonin was about 50 versus 75 pg/mL in magnesium-deficient versus adequate-diet rats.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"19edb320-2172-5fed-8881-23afca9e13d1","mechanism_event_label":"A nutrient shortage altered the measured hormone level in an animal experiment.","subject":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"object":{"id":"e9d33d62-e512-5d8c-9bc1-0d265482bbd8","slug":"rat-plasma-melatonin-concentration","display_name":"Rat plasma melatonin concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"19edb320-2172-5fed-8881-23afca9e13d1","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-magnesium-low-melatonin-event","event_type":"biochemical_relationship","label":"A nutrient shortage altered the measured hormone level in an animal experiment.","description":"Mean plasma melatonin was about 50 versus 75 pg/mL in magnesium-deficient versus adequate-diet rats.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0f0bc1f1-d18d-5652-bc1d-98f61f7ab65c","slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"},"role":"measured_hormone","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e9d33d62-e512-5d8c-9bc1-0d265482bbd8","slug":"rat-plasma-melatonin-concentration","display_name":"Rat plasma melatonin concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/melatonin-research/17172005.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"32a85d5fa095aeb2258c9ee44e480deb8c3292aafc9bd13edb4172d1743caf50\", \"start_char\": 0, \"end_char\": 969, \"text_sha256\": \"32a85d5fa095aeb2258c9ee44e480deb8c3292aafc9bd13edb4172d1743caf50\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Controlled dietary magnesium-deficiency pilot","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"150 versus 1000 ppm magnesium diet for four weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Animal dietary exposure; enzyme mechanism was not established by this experiment. No human intake threshold or universal repletion-failure rule can be derived.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Melatonin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Male Sprague-Dawley rats","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A nutrient shortage altered the measured hormone level in an animal experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[melatonin-p17172005] Dietary magnesium deficiency decreases plasma melatonin in rats. (2006). https://pubmed.ncbi.nlm.nih.gov/17172005/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Dark-phase plasma melatonin","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"d853ea78-1bd8-5ff9-b058-d34e2739535d","evidence_kind":"source_excerpt","locator":"Lines 760-771","start_line":760,"end_line":771,"excerpt":"### melatonin-magnesium-low-melatonin\nMean plasma melatonin was about 50 versus 75 pg/mL in magnesium-deficient versus adequate-diet rats.\nCondition category: nutrient_deficiency\nnutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A nutrient shortage altered the measured hormone level in an animal experiment.\norganism: Male Sprague-Dawley rats\ntissue_or_cell_type: Dark-phase plasma melatonin\nexperimental_model: Controlled dietary magnesium-deficiency pilot\nlimitations: Animal dietary exposure; enzyme mechanism was not established by this experiment. No human intake threshold or universal repletion-failure rule can be derived.\nexposure: 150 versus 1000 ppm magnesium diet for four weeks\nevidence_span: {\"source_cache\": \"artifacts/melatonin-research/17172005.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"32a85d5fa095aeb2258c9ee44e480deb8c3292aafc9bd13edb4172d1743caf50\", \"start_char\": 0, \"end_char\": 969, \"text_sha256\": \"32a85d5fa095aeb2258c9ee44e480deb8c3292aafc9bd13edb4172d1743caf50\"}\n[melatonin-p17172005] Dietary magnesium deficiency decreases plasma melatonin in rats. (2006). https://pubmed.ncbi.nlm.nih.gov/17172005/","model_system":"Controlled dietary magnesium-deficiency pilot","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [melatonin-p17172005] Dietary magnesium deficiency decreases plasma melatonin in rats. 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