{"id":"05906103-3d50-5b25-909e-0d27d9c5b799","stable_key":"35ec55a7-323c-5c28-979e-3bdafe9d5769:preparation-scope-blackcurrant-anthocyanin-preparation","predicate":"present_in_specified_preparation","statement":"The specified preparation contains anthocyanins; its experimental effects remain attached to the actual preparation. ","claim_class":"identity","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"78179e1c-38ee-5110-a17f-6aa8c1f7d19e","mechanism_event_label":"The specified preparation contains anthocyanins; its experimental effects remain attached to the actual preparation. ","subject":{"id":"a1b1c9c3-cafe-5dd6-a590-f56222d3a4cc","slug":"anthocyanins","display_name":"Anthocyanins","entity_type_key":"chemical_species"},"object":{"id":"208e948c-a7a4-5d34-8b16-81ec33dc7324","slug":"blackcurrant-anthocyanin-preparation","display_name":"Blackcurrant anthocyanin preparation in Matsumoto 2006","entity_type_key":"botanical"},"evidence_count":1,"mechanism_event":{"id":"78179e1c-38ee-5110-a17f-6aa8c1f7d19e","stable_key":"35ec55a7-323c-5c28-979e-3bdafe9d5769:preparation-scope-blackcurrant-anthocyanin-preparation-event","event_type":"preparation_composition","label":"The specified preparation contains anthocyanins; its experimental effects remain attached to the actual preparation. ","description":"**Animal ocular delivery has been observed.** Blackcurrant anthocyanins were detected intact in rat and rabbit ocular tissues after the reported oral and injected administrations. Route and species matter: these experiments cannot establish a human retinal concentration after eating berries, an equivalence to vitamin A, or enhanced rhodopsin regeneration in people. [Matsumoto et al., 2006](https://pubmed.ncbi.nlm.nih.gov/16635490/).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a1b1c9c3-cafe-5dd6-a590-f56222d3a4cc","slug":"anthocyanins","display_name":"Anthocyanins","entity_type_key":"chemical_species"},"role":"tested factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"208e948c-a7a4-5d34-8b16-81ec33dc7324","slug":"blackcurrant-anthocyanin-preparation","display_name":"Blackcurrant anthocyanin preparation in Matsumoto 2006","entity_type_key":"botanical"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary indexed abstract reviewed; full methods, figures, exact doses or endpoint-specific species assignments may remain unextracted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Preparation identity/scope; not isolated class causation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A food or extract contains other constituents. Membership is a navigation link and does not transfer its findings to isolated anthocyanins.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The specified preparation contains anthocyanins; its experimental effects remain attached to the actual preparation. ","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Comparative assessment of distribution of blackcurrant anthocyanins in rabbit and rat ocular tissues. | 2006 | DOI 10.1016/j.exer.2005.12.019 | PMID 16635490 | https://pubmed.ncbi.nlm.nih.gov/16635490/ | https://doi.org/10.1016/j.exer.2005.12.019","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 96-96; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4880f1ac-1fef-537b-a18f-1b3f22e418ad","evidence_kind":"source_excerpt","locator":"Lines 96-96","start_line":96,"end_line":96,"excerpt":"**Animal ocular delivery has been observed.** Blackcurrant anthocyanins were detected intact in rat and rabbit ocular tissues after the reported oral and injected administrations. Route and species matter: these experiments cannot establish a human retinal concentration after eating berries, an equivalence to vitamin A, or enhanced rhodopsin regeneration in people. [Matsumoto et al., 2006](https://pubmed.ncbi.nlm.nih.gov/16635490/).","model_system":"Preparation identity/scope; not isolated class causation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. 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