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(1983). https://pubmed.ncbi.nlm.nih.gov/6401349/ DOI: 10.1016/0026-0495(83)90154-3","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma urea-cycle intermediates","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2f987dde-e9be-5808-abc4-09910b3e1316","evidence_kind":"source_excerpt","locator":"Lines 853-864","start_line":853,"end_line":864,"excerpt":"### citrulline-lpi-precursor-response\nOral citrulline raised plasma urea-cycle intermediates more than oral arginine or ornithine in the LPI report.\nCondition category: normal\nnutrient_topic: Citrulline research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The alternative precursor improved downstream amino-acid availability in this disorder.\norganism: Human lysinuric protein intolerance\ntissue_or_cell_type: Plasma urea-cycle intermediates\nexperimental_model: Clinical oral-intermediate comparison\nlimitations: Brief indexed abstract; no trial size or dosing is inferred; not evidence that citrulline replaces lysine.\nexposure: Oral citrulline, arginine or ornithine\nevidence_span: {\"source_cache\": \"artifacts/citrulline-research/6401349.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e98ad3132221fd0deae9dd89d6c14a4f6b010655656a6e0ea44a7c47f2ca1545\", \"start_char\": 0, \"end_char\": 349, \"text_sha256\": \"e98ad3132221fd0deae9dd89d6c14a4f6b010655656a6e0ea44a7c47f2ca1545\"}\n[citrulline-p6401349] Oral administration of urea cycle intermediates in lysinuric protein intolerance: effect on plasma and urinary arginine and ornithine. 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